TWiV 409: A Nef is enough

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Jeremy Luban

Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles.

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Download TWiV 409 (75 MB .mp3, 124 min)
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Links for this episode

• No recovery in PACE trial (virology blog) 6:10
• The real PACE data (virology blog) 7:20
• Contagious Thinking 12:10
• Florida DOH daily Zika update 28:50
• Congress does not fail on Zika (NPR) 29:10
• Nef history (Luban lab) 1:36:15
• Nef excludes SERINC from virions (Nature) 33:10
• SERINC counters Nef (Nature) 35:55
• ASM Grant Writing Online Course 2:00:00
• Letters read on TWiV 409 11:30, 1:41:35

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world’s best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 38:20

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. 0:50, 1:39:40

Weekly Science Picks 1:44:30

Alan – Migration in Motion
Dickson – Beautiful Chemistry
Rich – XKCD Timeline of Earth Temperature
Kathy –  Vaccine Heroes from Vaccine Education Center
Jeremy – CIDRAP posters and Demon in the Freezer
Vincent – People Peas and Pathogens

Listener Picks

Matlock – Science isn’t broken

Send your virology questions and comments to twiv@microbe.tv