Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine.
TWiV 465: Theodora the explorer
- October 29, 2017
- Tagged as: AIDS, animal model, APOBEC3H, CRNA, deamination, dsRNA, hiv-1, pigtail macaque, restriction factor, viral, virology, virus, viruses, X-ray structure
Theodora Hatziioannou joins the TWiV team to discuss a macaque model for AIDS, and how a cell protein that blocks HIV-1 infection interacts with double-stranded RNA.
TWiV 409: A Nef is enough
- October 2, 2016
- Tagged as: AIDS, endocytosis, hiv, Nef, restriction factor, SERINC, siv, viral, virion, virology, virus, viruses
Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles.