TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Download TWiV 1037 (83 MB .mp3, 116 min)
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Links for this episode
- MicrobeTV Discord Server
- MicrobeTV store at Cafepress 4:21
- Research assistant position in Rosenfeld Lab CBER/FDA (pdf) 4:32
- VITT-like disorder after adenovirus infection (NEJM) 5:14, 28:28
- The clot thickens (TWiV 842) 6:36
- Lessons from VITT (Nat Rev Immunol) 23:13
- Pan-sarbecovirus neutralizing mAb (Sci Adv) 36:40
- Letters read on TWiV 1037 1:20:49
- Timestamps by Jolene. Thanks!
Weekly Picks 1:33:48
Dickson – Rho Ophiuchi nebula showing massive star formation. James Webb Space Telescope
Brianne – Question Mark in Space?
Kathy – Quammen interview with Walter Isaacson
Rich – Chrome Music Lab
Vincent – Matters Microbial
Listener Picks
Tom – The (second) deadliest virus
Charles – We Will All Go Together When We Go and So Long Mom (A Song for World War III)
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
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