Vivianne explains how early in Alzheimer’s disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response.
Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release conveys causal associations but not reward prediction errors, thereby challenging the dominant theory of reward learning.
Junjie from Jason’s lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome.
TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A.
TWiN 37: Microglia at the crossroads
- January 23, 2023
- Tagged as: microglia, neurobiology, neuroinflammation, neuroscience, nomenclature
TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne…
TWiN 36: Unbearable neurologists
- January 3, 2023
- Tagged as: Alzheimer's disease, brain, nervous system, neurobiology, neurology, neuron, neuroscience
TWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips implanted in the human brain.
Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression.
TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice.
TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull.
TWiN 32: Relearning how to move after stroke
- August 2, 2022
- Tagged as: cortex, neurobiology, neuroscience, recovery after stroke, striatum, stroke
TWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity together.
About the Hosts
Jason Shepherd, Ph.D.
Vivianne Morrison, Ph.D.
Tim Cheung, Ph.D.
Vincent Racaniello, Ph.D.