TWiM 262: Spot on with T4SS modulators

TWiM welcomes new host Petra, and explains how a small protein helps ensure that E. coli utilizes a preferred carbon source, and a screening strategy to identify inhibitors of the type IV secretion system that is essential for virulence of a variety of bacterial pathogens.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin

Right click to download TWiM #262 (57 MB .mp3, 70 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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TWiM 261: Overwhelming microbial greatness

Mark returns to TWiM to join in a discussion of soil microbiota as game-changers in restoration of degraded lands, and discovery of a centimeter-long bacterium, the biggest yet discovered.

Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt

Guest: Mark O. Martin

Right click to download TWiM #261 (57 MB .mp3, 70 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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TWiM 260: Carnivorous vulture bees

In this food-centric TWiM, we reveal the microbiomes of carnivorous vulture bees and of Gala apples from all over the world.

Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt

Right click to download TWiM #260 (45 MB .mp3, 62 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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TWiM 259: Sea sawdust

Mark Martin returns to TWiM for a discussion of the frightening global burden of bacterial antibiotic resistance, and a solution to the problem of daylight nitrogen fixation in a cyanobacterium, despite the incompatibility of nitrogenase with oxygen produced during photosynthesis.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt

Guest: Mark O. Martin

Right click to download TWiM #259 (45 MB .mp3, 62 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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TWiM 258: A tick’s meal

TWiM explains how bacterial symbionts regulate tick blood feeding activity, and the reasons why antibiotics exist.

Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt

Right click to download TWiM #258 (45 MB .mp3, 61 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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TWiM 257: I have one word for you: plastics

On this episode of TWiM, how phages prevent other phages from invading their hosts without blocking their own reproduction, and plastic-degrading potential of microbes across the Earth.

Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt

Right click to download TWiM #257 (45 MB .mp3, 61 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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TWiM 256: An mRNA vaccine against ticks

TWiM discusses antigenic variation within dengue virus serotypes, and an mRNA vaccine that induces antibodies against tick proteins and prevents transmission of the Lyme disease agent.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt

Right click to download TWiM #256 (36 MB .mp3, 49 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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TWiM 255: Fleaing the plague

TWiM reveals a study showing that positive interactions among bacteria are far more common than previously thought, and how acquisition of a single gene enabled Yersinia pestis to expand the range of mammalian hosts that sustain flea-borne plague.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt

Right click to download TWiM #255 (36 MB .mp3, 49 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 254: Episymbionts are good for you

Mark Martin returns to TWiM for a discussion of the observation that Gram’s stain does not cross the bacterial cytoplasmic membrane, and suppression of gingival inflammation and bone loss through host modulation caused by episymbiotic Saccharibacteria. 

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt

Guest: Mark O. Martin

Right click to download TWiM #254 (36 MB .mp3, 49 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 253: Cell growth and cell size with Petra Levin

Petra Levin joins TWiM to tell three stories from her laboratory: how starvation induces shrinkage of the bacterial cytoplasm; plasticity of E. coli cell wall and how it influences antibiotic resistance across different environments; and induction of antibiotic resistance by Triclosan. 

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt

Guest: Petra Levin

Right click to download TWiM #253 (36 MB .mp3, 49 minutes)

Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email.

Become a Patron of TWiM!

Links for this episode:

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

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