TWiM 288: Cancer and E. coli

TWiM describes a potential connection between a bacterial protein that damages DNA and human cancers, and how to synthesize antimiicrobial natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic.

Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin

Right click to download TWiM #288 (49 MB .mp3, 67 minutes)

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Music used on TWiM is by Ronald Jenkees.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 287: When replicas do not replicate

TWiM investigates the high variability in the rate and amount of current production from microbial fuel cells, and how bacteria link their growth rate to external nutrient conditions via a protein that functions as a cellular rheostat.

Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin

Right click to download TWiM #287 (38 MB .mp3, 51 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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Music used on TWiM is by Ronald Jenkees.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 286: Integrons and invasion

TWiM reveals environmental integrons, bacterial genetic elements notorious for their role in spreading antibiotic resistance, and how Salmonella invasion is controlled by competition among intestinal chemical signals.

Hosts: Vincent Racaniello, Michael Schmidt, and Michelle Swanson

Right click to download TWiM #286 (44 MB .mp3, 60 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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Music used on TWiM is by Ronald Jenkees.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 285: How plague got deadly

TWiM reveals a new type of satellite virus that requires only phage tails for producing infectious virus particles, and that highly virulent plague bacteria differs from its innocuous enteric predecessor by its resistance to lysis by human complement.

Hosts: Vincent Racaniello and Michael Schmidt

Right click to download TWiM #285 (44 MB .mp3, 60 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 284: Flies, pigs, and squid

TWiM reveals housefly dispersal of antimicrobial resistant bacteria, and a reproductive organ in squid linked to symbiotic bacteria.

Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin

Right click to download TWiM #284 (44 MB .mp3, 60 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 283: Quorum sensing in the gut

TWiM reveals quorum-sensing systems that regulate intestinal inflammation and permeability caused by P. aeruginosa, and how plasmids manipulate bacterial behavior through translational regulatory crosstalk.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson

Right click to download TWiM #283 (44 MB .mp3, 60 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 282: At-home evolution with yeast

TWiM presents a protocol for evolving caffeine-tolerant yeast by high school students in the home, and how predator-prey dynamics change when multiple bacteria grow together in biofilms.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin

Guest: Mark O. Martin

Right click to download TWiM #282 (44 MB .mp3, 60 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 281: Microbes making jet fuel

TWiM explains the synthesis in bacteria of new energy-dense biofuels that can replace rocket and jet fuels, and the use of nanopore sequencing to improve diagnosis and treatment of patients with serious infections.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin

Right click to download TWiM #281 (44 MB .mp3, 60 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

Become a Patron of TWiM!

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 280: They forgot to divide

TWiM explains how magnesium modulates cell division frequency of a soil bacillus, and killing of fungi by Acinetobacter baumannii via a Type VI DNase effector.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin

Right click to download TWiM #280 (36 MB .mp3, 59 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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•Magnesium modulates cell division frequency (J Bacteriol)
•A. baumannii kills fungi (mBio)

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 279: A road map for successful phage therapy

TWiM describes successful phage therapy against a mycobacterial lung infection, and how encapsulation of the cell wall protects S. pneumoniae from its major peptidoglycan hydrolase and host defenses.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin

Right click to download TWiM #279 (36 MB .mp3, 59 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

Become a Patron of TWiM!

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

About the Hosts of TWiM

Vincent Racaniello, Ph.D. (@profvrr) is Higgins Professor of Microbiology & Immunology at Columbia University Medical Center. He has been studying viruses for over 40 years. He teaches virology to undergraduate and graduate students, as well as medical, dental, and nursing students. His lectures are available online at iTunes University, YouTube, and Coursera.


Michael Schmidt, Ph.D. (TWiM) is the Professor and Vice Chairman of Microbiology and Immunology and Director of the Office of Special Programs at the Medical College of South Carolina. Dr. Schmidt is leading a team of infectious disease specialists from three health sciences centers and engineers from industry.

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