TWiM 293: Aerosol phage therapy, alpha-gal aptamers for MRSA

TWiM explains personalized aerosilized phage therapy for a chronic lung infection, and using the combination of antibiotic and a DNA molecule that binds alpha-gal to reduce S. aureus infection in vivo.

Hosts: Vincent Racaniello and Michael Schmidt

Right click to download TWiM #293 (51 MB .mp3, 70 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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Music used on TWiM is by Ronald Jenkees.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 292: Breast milk bioactives

TWiM reveals that breast milk bioactives are essential for development of the infant microbiome and immunity, and how capsule mutants of Klebsiella pneumoniae can affect bacterial pathogenesis.

Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin

Right click to download TWiM #292 (43 MB .mp3, 60 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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Music used on TWiM is by Ronald Jenkees.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 291: Biogeography of tectonics and teeth

TWiM explains how photoferrotrophic bacteria initiated plate tectonics over 2500 million years ago, and how two bacteria work together to cause childhood tooth decay.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin

Guest: Mark O. Martin

Right click to download TWiM #291 (45 MB .mp3, 62 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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Music used on TWiM is by Ronald Jenkees.

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TWiM 290: Houston, we have Mimi Goldschmidt

From ASM Microbe 2023 in Houston, TWiM speaks with Mimi Goldschmidt about her remarkable career in microbiology which included training astronauts to safely bring moon rocks back to Earth.

Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin

Guest: Mimi Goldschmidt

Right click to download TWiM #290 (34 MB .mp3, 47 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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Music used on TWiM is by Ronald Jenkees.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 289: Viral defense and counter-defense

TWiM highlights viral defense and counter-defense: cGAS mediated ubiquitination to counter infection, and viral sponges that sequester nucleotide signals to inactivate immunity.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson and Petra Levin

Right click to download TWiM #289 (42 MB .mp3, 58 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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Music used on TWiM is by Ronald Jenkees.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 288: Cancer and E. coli

TWiM describes a potential connection between a bacterial protein that damages DNA and human cancers, and how to synthesize antimiicrobial natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic.

Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin

Right click to download TWiM #288 (49 MB .mp3, 67 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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Music used on TWiM is by Ronald Jenkees.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 287: When replicas do not replicate

TWiM investigates the high variability in the rate and amount of current production from microbial fuel cells, and how bacteria link their growth rate to external nutrient conditions via a protein that functions as a cellular rheostat.

Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin

Right click to download TWiM #287 (38 MB .mp3, 51 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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Music used on TWiM is by Ronald Jenkees.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 286: Integrons and invasion

TWiM reveals environmental integrons, bacterial genetic elements notorious for their role in spreading antibiotic resistance, and how Salmonella invasion is controlled by competition among intestinal chemical signals.

Hosts: Vincent Racaniello, Michael Schmidt, and Michelle Swanson

Right click to download TWiM #286 (44 MB .mp3, 60 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

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Music used on TWiM is by Ronald Jenkees.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 285: How plague got deadly

TWiM reveals a new type of satellite virus that requires only phage tails for producing infectious virus particles, and that highly virulent plague bacteria differs from its innocuous enteric predecessor by its resistance to lysis by human complement.

Hosts: Vincent Racaniello and Michael Schmidt

Right click to download TWiM #285 (44 MB .mp3, 60 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

Become a Patron of TWiM!

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 284: Flies, pigs, and squid

TWiM reveals housefly dispersal of antimicrobial resistant bacteria, and a reproductive organ in squid linked to symbiotic bacteria.

Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin

Right click to download TWiM #284 (44 MB .mp3, 60 minutes)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.

Become a Patron of TWiM!

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

About the Hosts of TWiM

Vincent Racaniello, Ph.D. (@profvrr) is Higgins Professor of Microbiology & Immunology at Columbia University Medical Center. He has been studying viruses for over 40 years. He teaches virology to undergraduate and graduate students, as well as medical, dental, and nursing students. His lectures are available online at iTunes University, YouTube, and Coursera.


Michael Schmidt, Ph.D. (TWiM) is the Professor and Vice Chairman of Microbiology and Immunology and Director of the Office of Special Programs at the Medical College of South Carolina. Dr. Schmidt is leading a team of infectious disease specialists from three health sciences centers and engineers from industry.

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