This Week in Microbiology

TWiM 62: Breaking bad and protein chain mail

August 21, 2013

Hosts: Vincent Racaniello and Michael Schmidt

Vincent and Michael discuss how infection with influenza A virus disperses Streptococcus pneumoniae biofilms leading to disease, and an amazing protein chainmail in a viral capsid.

Right click to download TWiM #62 (55 MB .mp3, 80 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

Interkingdom signaling induces biofilm dispersion (mBio)
What makes good bacteria go bad? (NPR)
Movie of S. pneumoniae motility (legend – scroll down)
Protein chainmail (Cell)
Protein chainmail in a viral capsid (Science)
Letters read on TWiM 062

Send your microbiology questions and comments to [email protected]

TWiM 61: The irony of probiotics

August 7, 2013

Hosts: Vincent Racaniello, Elio Schaechter and Michele Swanson.

Vincent, Elio, and Michele review how horizontal gene transfer from bacteria to an insect genome enables a tripartite nested mealybug symbiosis, and how probiotic bacteria work by competing for iron in the intestine.

Right click to download TWiM #61 (44 MB .mp3, 60 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

Horizontal gene transfer from bacteria to an insect genome (Cell)
Debugging symbiosis (TWiM #17)
Probiotic bacteria compete for iron (Cell Host Microbe)
Intestinal irony (Cell Host Microbe)
An inflamed gut is good for Salmonella (TWiM #27)
Letters read on TWiM 061

Send your microbiology questions and comments to [email protected]

TWiM 60: Microbial electrochemistry and diversity-generating retroelements

July 24, 2013

Hosts: Vincent Racaniello, Elio Schaechter and Michael Schmidt

Vincent, Elio, and Michael discuss how an error-prone reverse transcriptase produces enormous diversity in a Legionella protein, and using microbes to convert waste into bioelectricity and chemicals.

Right click to download TWiM #60 (50 MB .mp3, 71 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

Legionella diversity-generating retroelement (PNAS)
Microbial Electrochemical Technologies (Science)
Letters read on TWiM 060

Send your microbiology questions and comments to [email protected]

TWiM 59: Are viruses part of our immune system?

July 10, 2013

Hosts: Vincent Racaniello and Michael Schmidt

Vincent and Michael discuss the finding that bacteriophage might be part of the mucosal antimicrobial defense system.

Right click to download TWiM #59 (61.5 MB .mp3, 84 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

Bacteriophage adhering to mucus provide immunity (PNAS)
Sticky bacteriophage protect animal cells (PNAS)
Viruses might provide mucosal immunity (Virology blog)
Image source
Letters read on TWiM 059

Send your microbiology questions and comments to [email protected]

TWiM 58: The brain microbiome?

June 20, 2013

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter

Vincent, Elio and Michael review how underground mycelial networks carry signals that warn neighboring plants of aphid attack, and the presence of bacteria in the human brain.

Right click to download TWiM #58 (59 MB .mp3, 81 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

Underground mycelial networks carry warning signals to plants (Ecol Lett)
Plant viruses induce deceptive chemical signals (PNAS)
Brain microbial populations (PLoS One)
Letters read on TWiM 058

Send your microbiology questions and comments to [email protected]

TWiM 57: Updating the human gut microbiome to degrade seaweed

June 5, 2013

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter

Vincent, Elio and Michael discuss fungi that use pheromones to trap nematodes, and how genes obtained from marine bacteria help gut bacteria degrade algal carbohydrates.

Right click to download TWiM #57 (42.5 MB .mp3, 59 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

Nematode-trapping fungi sense pheromones (Curr Biol)
Gut bacteria catabolize red seaweed glycans with genes from marine microbes (PNAS)
Fecal transplants in the good old days (S Falkow)
A safe hospital room of the future
Letters read on TWiM 057

Send your microbiology questions and comments to [email protected]

TWiM 56: Live at ASM in Denver

May 24, 2013

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter

Guests: Andrew Camilli, Ferric Fang, Suzanne Fleiszig, and Michele Swanson

Vincent, Elio and Michael recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Andrew, Ferric, Suzanne, and Michelle about their research on a phage system for evading innate immunity, retractions of research papers, bacterial infections of the eye, and cytoplasmic defenses against intracellular bacteria.

Download TWiM #56 (73 MB .mp3, 102 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

A bacteriophage evades host immunity (Nature)
Misconduct accounts for most retracted papers (PNAS)
Males overrepresented in scientific misconduct (mBIO)
Why does the cornea resist P. aeruginosa infection? (Am. J. Opthal.)
Inflammosome components coordinate autophagy and pyroptosis (mBIO)

Send your microbiology questions and comments [email protected]

TWiM 55: In the copper room

April 24, 2013

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter.

Vincent, Elio and Michael discuss the finding that copper surfaces reduce microbial burden and hospital-acquired infections in the intensive care unit.

Download TWiM #55 (58.5 MB .mp3, 85 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

Copper reduces microbial burden on hospital surfaces (J Clin Micr)
Copper continuously limits bacterial on hospital bedrails (Inf Cont Hosp Epi)
Copper reduces healthcare-associated infection in the ICU (Inf Cont Hosp Epi)
Pathogens in the contaminated hospital environment (Inf Cont Hosp Epi)
Resistance on the surface (TWiM #47)
Letters read on TWiM 055

Send your microbiology questions and comments to [email protected]

TWiM 54: Dueling injectors and the microgenderome

April 10, 2013

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter

Vincent, Elio, and Michael review how sex-dependent differences in the mouse microbiome regulate type I diabetes, and counterattack among bacteria.

Download TWiM #54 (53 MB .mp3, 72 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Send your microbiology questions and comments to [email protected]

TWiM 53: Live in Manchester

March 29, 2013

Hosts: Vincent Racaniello, Laura Piddock, David Harper, Kalin Vetsigian, and Paul Williams

Vincent, Laura, David, Kalin and Paul get together at the Society for General Microbiology meeting in Manchester, England to talk about next-generation approaches to antimicrobial therapy.

Download TWiM #53 (44 MB .mp3, 61 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

What is antibiotic action? (YouTube)
The crisis of no new antibiotics (Lancet)
Tackling antibiotic resistance (Nat Rev Micro)
Quorum sensing and social networking (J Roy Soc Interface)
Streptomyces interaction networks in soil (PLoS Biol)
What counters antibiotic resistance in nature? (Nat Chem Biol)
Clinical trials and bacteriophage therapy (J Mol Gen Med)

Send your microbiology questions and comments to [email protected]

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TWiM 62: Breaking bad and protein chain mail

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TWiM 61: The irony of probiotics

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TWiM 60: Microbial electrochemistry and diversity-generating retroelements

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TWiM 59: Are viruses part of our immune system?

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TWiM 58: The brain microbiome?

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TWiM 57: Updating the human gut microbiome to degrade seaweed

Links for this episode:

TWiM 56: Live at ASM in Denver

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TWiM 55: In the copper room

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TWiM 54: Dueling injectors and the microgenderome

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TWiM 53: Live in Manchester

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