Rich Condit joins Nels and Vincent to explain how a vaccinia virus protein customizes ribosomes to favor the translation of viral mRNAs with a stretch of A residues in the 5′-untranslated region.
Hosts: Nels Elde and Vincent Racaniello
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- Rich Condit with Harry Noller (scroll down) 10:19
- Trans-Kingdom mimicry? (Nature) 9:25
- More on RACK1 (Nat Struct Mol Biol) 14:40, 22:21
- Image credit
- Letters read on TWiEVO 21 1:25:03
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Science Picks 1:32:07
Rich – Sniffing out significant “Pee values”
Nels – Cuttlefish mimicking a hermit crab (evolutionary context)
Vincent – Our first bioRxiv submission!
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Hi Rich , Nels and Vincent,
First of all , I love your show. I am a very faithful follower of Twievo and Twiv. Please Keep up the great work.
Just a little note, that comes out of my slight disappointment. You give all the credit in the IRES-Rack1 connection to a Sara Cherry genome-wide screen paper (PMC548945) , in which RACK1 is not even mentioned in the main text. This paper identifies 66 ribosomal proteins (ribosome is roughly composed of 80 proteins) as important for IRES translation ! Please check PMC4243054 that formally proves that RACK1 is important for IRES translation. The reason of my ”childish” disappointment is that I am the first author on this paper and spent 5 years of my life working on it 🙂
No big deal or hard feelings tho! I know that all of us can miss stuff in the literature and are more likely to remember faces and talks we see at conferences.
Again, I love your show and will always be an ardent follower.
Thanks for all your efforts and work making my commute from SF to Stanford every day more pleasant !
Sorry Karim! I fully understand your disappointment. We will fix in a future episode. Vincent.