TWiV 27: Leaving latency

April 4, 2009

Hosts: Vincent Racaniello, Dick Despommier, Alan Dove, and Saul Silverstein

Vincent, Dick, Alan, and Saul Silverstein revisit an ebolavirus needlestick accident, and discuss the role of TLR3 in formation of Negri bodies, a New England college closed by norovirus gastroenteritis, hand, foot, and mouth disease outbreak in China, and the exit of herpes simplex virus from latency by synthesis of VP16.

Click the arrow above to play, or right-click to download TWiV #27 (49 MB .mp3, 71 minutes)

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Links for this episode:

  • Update on ebolavirus needlestick accident
  • Formation of Negri bodies depend upon TLR3
  • Norovirus outbreak closes New England college
  • Hand, foot, and mouth disease outbreak in China
  • Synthesis of VP16 coordinates herpes simplex virus exit from latency

Science blog of the week: Biocurious
Science podcast pick of the week: NPR’s Science Friday
Science book of the week: A Conspiracy of Cells by Michael Gold
Dick’s pick: Andros Island Bonefish Club
Saul’s pick: Secret Science Club

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2 comments on “TWiV 27: Leaving latency

  1. Seattle82m Apr 9, 2009

    not sure why people are not living comments, poor PR or the common LAZY virus. I just want to say I love the podcast, listen to it at work and share my knowledge and interesting info with coworkers (who become to think I'm crazy, my last podcast I was in love with was about cancer, lol). Keep up the awesome job and thank you for your time and for sharing your great knowledge with us, listeners. (oh, I'm on episode four 🙂 )
    Take care guys!

  2. Pritesh Aug 29, 2010

    Can you do a follow up on the negri body research paper ?? It looks really interesting.

    I am still confused what the role of TLR-3 is ?? Is it a sensor which eventually leads to synthesis of antiviral response …
    or it has beneficial role for virus ?? How come virus multiplication is reduced when TLR 3 is knocked out ??