Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design.
Hosts: Vincent Racaniello and Rich Condit
Guest: Jason McLellan
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Download TWiV 1003 (47 MB .mp3, 65 min)
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Links for this episode
- MicrobeTV Discord Server
- MicrobeTV store at Cafepress
- Become a member of ASV (asv.org)
- The New City by Dickson Despommier
- Prefusion-stabilized SARS-CoV-2 spikes (Science)
- Structure-based vaccine design (Curr Opin Immunol)
- Prefusion-stabilized SARS-CoV-2 S2-only antigen (Nat Comm) 35:25
- Stabilized coronavirus spike stem elicits broadly protective antibody (Cell Rep)
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
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