Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein.
Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex.
The TWiVers discuss the declining readability of scientific texts, and review the use of self-inactivating rabies virus for tracing neural circuits.
The complete TWiV team reviews evidence for sensing of herpesviral DNA in the nucleus by the cell protein IFI16.