From ASM Microbe in Houston, Texas, Vincent speaks with Eddie Holmes about the evidence that SARS-CoV-2 spilled over into humans in the Huanan Market in Wuhan, absence of evidence for other origins, and his work on the virosphere.

The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners.