Steve Goff returns to TWiV to discuss the work of his laboratory on how retroviral genomes are silenced in infected cells.
TWiV 516: HUSH little virus, don’t you transcribe
- October 21, 2018
- Tagged as: chromatin, hiv, human immunodeficiency virus, HUSH complex, LINE-1, promoter, proteasome, provirus, siv, transcriptional repression, viral, virology, virus, viruses, Vpr, Vpx
Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex.