Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection.

Vincent, Dick, and Alan review a new macaque model for HIV-1 infection, a possible role for Epstein-Barr virus in multiple sclerosis, accidental release of H5N1 by a vaccine company, resistance of frogs to virus infection, and extreme virology – the biggest and smallest viruses and viral genomes.