Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies.
The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein.
Two Coynes join the TWiV overlords to explain their three-dimensional culture model of polarized intestinal cells for studying enterovirus infection.
The TWiV team discusses the possible association of the respiratory pathogen enterovirus D68 with neurological disease.
TWiV 328: Lariat tricks in 3D
- March 15, 2015
- Tagged as: 3Dpol, coxsackievirus, enterovirus, enterovirus 71, mRNA, NLS, nuclear localization signal, nucleus, picornavirus, poliovirus, Prp8, RdRp, rhinovirus, RNA polymerase, snurp, spliceosome, splicing, viral, virology, virus
The TWiVocateurs discuss how the RNA polymerase of enteroviruses binds a component of the splicing machinery and inhibits mRNA processing.
Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States.
The TWiV team discusses recent cases of polio-like paralysis in California, and the virome of 14th century paleofeces.
Vincent, Rich, Alan, and Dickson speak with Alfred Sacchetti, MD, Chief of Emergency Services at Our Lady of Lourdes Medical Center, about viral infections encountered in the emergency room.
Vincent, Alan, and Hamish Young discuss bacteriophages in viral vaccines, enteroviruses and diabetes, inhibition of Hendra and Nipah virus replication by the malaria drug chloroquine, and viroids.