TWiV 1145: Heartbeats and hoofbeats

TWiV reviews a case of polio in Gaza, more Mpox, COVID-19 boosters, effectiveness of Ebola virus vaccine, measles cases across the US, an endogenous retroviral envelope protein that regulates human cardiomyocyte development, and submergence of an encephalitic alphavirus caused by receptor shifts.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Weekly Picks 1:24:12

Kathy – Googlegangers and AWWW clip
Rich – RP FLIP (floating instrument platform)
Alan – Big labs are bad for careers
Vincent – So You’re Underwater: Why Do You See That Circle of Light Above You?

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

TWiV 1144: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses Dr. Fauci’s case of West Nile virus, polio vaccine campaign develops in Gaza, disease that associates with Oropouche virus, mpox: vaccines, clinical trial for mpox antiviral and the WHO strategic preparedness and response plan before reviewing the recent statistics on SARS-CoV-2 infection, how to obtain free COVID tests, EUA for updated Novavax COVID vaccine, ISDA support of and where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if nirmatrelvir/ritonavir is effective at preventing hospitalization of high risk patients, incidence of mental illness in the vaccinated and unvaccinated, the effect of amubarvimab/romlusevimab on long COVID outcome, having an evidence based approach to long COVID and how fibrin drives thromboinflammation and neuropathology in COVID-19.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 1143: SARS-CoV-2 gone wild, with a side of rice

TWiV discusses WHO declaration of Mpox as a public health emergency of international concern, Sweden reports first case of clade 1b outside of Africa, can household pets be productively infected with monkeypox virus, widespread exposure to SARS-CoV-2 in wildlife communities, and modulation of plant defenses by insect salivary GAPDH benefits viral transmission.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Weekly Picks 1:27:00

Dickson – NASA Confirms Evidence That Liquid Water Flows on Today’s Mars
Kathy – TBP for PCR internal control
Rich –  xmACIS2 compares the data in the ACIS database to that in GHCN-Daily
Alan – Larry, the world’s most highly cited cat
Vincent – The Viral Paleontologist Who Unearths Pathogens’ Deep Histories

Listener Pick

Ryan – Mpox emergencies AP News one and two
Rona – Up in smoke
David – Ode to Joy (YouTube, TikTok)

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

TWiV 1142: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses global transmission of mpox, the different clades of the virus and associated pathogenesis, vaccination vs antiviral therapy against mpox and the US’s aid response for controlling the African outbreak before reviewing the recent statistics on SARS-CoV-2 infection, authorization and approval of updated COVID vaccines, the economic benefit of an annual COVID vaccine and if the first updated vaccines against XBB.1.5 were effective, where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and how long COVID differs in children and adolescents.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 1141: Being green with the Red Queen

TWiV discusses the spread of monkeypox virus clade 1b in Africa, COVID drops to tenth leading cause of death in the US, response to detection of poliovirus in Gaza, mechanism of MIS-C after SARS-CoV-2 infection, neonatal Fc receptor is a pan-arterivirus receptor, and antiviral immunity in plants mediated by protein arginine methyltransferase 6.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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Weekly Picks 1:28:32

Brianne – Kate Douglass: Olympian and Statistician (Swimming in Data)
Dickson – Women of recent note: Kamala Harris (Democratic Party presidential candidate); Katie Ladecky (10,000 meters); Sydney McLaughlin-Levrone (400 meter hurdles); Gabby Thomas, Sha’Carri Richardson, Melissa Jefferson, and Twanisha Terry (4 x 100 relay); women’s basketball team
Rich – Texas State University Forensic Anthropology Research Facility
Vincent – Sea lion ‘camera crews’ capture new footage of ocean floor

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

TWiV 1140: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 1139: Long COVID with Dr. Judith Bruchfeld

Vincent travels to the Karolinska Institute in Stockholm on 31 May 2024 to meet with Dr. Judith Bruchfeld and discuss her research on the etiology and treatment of Long COVID.

Hosts: Vincent Racaniello

Guest: Judith Bruchfeld

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Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

TWiV 1138: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 1137: Dengue is not BANAL

TWiV discusses a twice-yearly antiviral for prevention of AIDS, the WHO pandemic plan, West Nile resurgence in the US, the BANAL SARS-CoV-2 related viruses reproduce in human cells but do not transmit among animal hosts, and an amino acid change in dengue virus that enhances midgut replication in mosquitoes but reduces pathogenicity in humans.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Weekly Picks 1:16:33

Kathy – Using big data to improve traffic light timing
Rich – Dillo Dirt
Alan – Dueling Banjos on banjo and kora
Vincent – The world’s most expensive dinosaur and more

Listener Pick

Mike – Science through a glass darkly
Lisa – “On A Mission“ Season Four

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

TWiV 1136: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses how the pandemic may have affected our trust in physicians and hospitals and if waiting longer to make strain selection for the seasonal influenza vaccine would be advantageous before reviewing the recent statistics on SARS-CoV-2 infection, how different CVODI-19 vaccines effect the cardiovascular system, if the a third of either COVID-19 mRNA vaccine is effective, where to find PEMGARDA, if convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and the long term consequences of a SARS-CoV-2 infection on human health including incidences of diabetes, respiratory problems, hearing loss and maternal-fetal health.

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  • In physicians and hospitals, we trust (JAMA Network) 2:50
  • Are there benefits for delaying seasonal influenza vaccine selections (JID) 9:05
  • Personal protective effect for wearing surgical face masks in public spaces (the BMJ) 14:02
  • COVID-19 national trend (CDC) 16:28
  • COVID-19 deaths (CDC)
  • Cardiovascular safety of different COVID-19 vaccination (Nature Comm) 18:12
  • Effectiveness of a third dose of mRNA-1273 versus BNT162b2 among older adults (Vaccine) 20:11
  • Where to get pemgarda (Pemgarda)
  • CDC Quarantine guidelines (CDC)
  • Early phase of SARs-CoV-2 infection (COVID.gov)
  • NIH COVID-19 treatment guidelines (NIH)
  • Infectious Disease Society guidelines for treatment and management (ID Society)
  • Drug interaction checker (University of Liverpool)
  • Molnupiravir safety and efficacy (JMV)
  • Convalescent plasma recommendation for immunocompromised (ID Society)
  • Managing healthcare staffing shortages (CDC)
  • Steroids, dexamethasone at the right time (OFID)
  • Anticoagulation guidelines (hematology.org)
  • Incidence of diabetes after SARS-CoV-2 infection (The Lancet Diabetes & Endocrinology) 23:30
  • Post-COVID-19 respiratory sequelae two years after hospitalization (The Lancet Regional Health) 25:49
  • Incidence of hearing loss following COVID-19 among young adults (eClinical Medicine) 28:44
  • The effect of long-term COVID-19 infection on maternal and fetal complications (Scientific Reports) 31:05
  • Contribute to our Floating Doctors fundraiser 32:58
  • Letters read on TWiV 1136 33:38
  • Dr. Griffin’s COVID treatment summary (pdf)
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Brianne Barker, Ph.D.


Rich Condit, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


Kathy Spindler, Ph.D.


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