TWiM 75: Pellicles on pickle jars

rotting-teethHosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt and Michele Swanson

Vincent, Elio, Michael, and Michelle discuss a symbiosis between a bacterium and fungus that increases the virulence of oral biofilms, and the assembly of amyloid fibers, which are needed for biofilm formation.

Right click to download TWiM#75 (59 MB .mp3, 81 minutes).

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TWiM 74: It came from the Siberian permafrost

giant virusHosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt.

Vincent, Elio, and Michael discuss a huge 30,000 year old virus recovered from Siberia, and nested symbiosis facilitated by horizontal gene transfer from bacteria to insect.

Right click to download TWiM#74 (51 MB .mp3, 70 minutes).

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TWiM 73: Eyeing root nodule development

Redon cyclopsHosts: Vincent Racaniello, Michael Schmidt and Michele Swanson

Vincent, Michael, and Michele discuss how soil-dwelling bacteria induce the formation of root nodules on legumes via a protein called CYCLOPS.

Right click to download TWiM#73 (57.5 MB .mp3, 80 minutes).

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TWiM 72: The benefits of virulence

Mammalian Drosophila intestineHosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt and Michele Swanson

Vincent, Elio, Michael, and Michele review how microbial virulence can be increased as a consequence of community surveillance and adaptation to macrophages.

Right click to download TWiM#72 (53 MB .mp3, 74 minutes).

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TWiM 71: Colon cancer’s little shop of horrors

Butyric acidHosts: Vincent Racaniello, Michael Schmidt and Michele Swanson

Vincent, Michael, and Michele explain how the gut microbiome modulates colon tumorigenesis, and regulation of intestinal macrophage function by the microbial metabolite butyrate.

Right click to download TWiM#71 (57 MB .mp3, 78 minutes).

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TWiM 70: A paroxysmal cough

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt and Michele Swanson

Vincent, Elio, Michael, and Michele discuss evidence that the acellular pertussis vaccine fails to prevent infection and transmission in nonhuman primates, and the use of bacterial cytological Pertussis world map by-wiki-Lokal Profilprofiling to identify pathways targeted by antibiotics.

Right click to download TWiM#70 (53 MB .mp3, 73 minutes).

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TWiM 69: Bacterial DNA in the human genome

acinetobacterHosts: Vincent Racaniello, Elio Schaechter, Jo Handelsman and Michele Swanson

Vincent, Elio, Jo, and Michele review evidence for bacterial DNA integrated into the human genome, and control of the symbiont population in an insect midgut.

Right click to download TWiM #69 (51 MB .mp3, 71 minutes).

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TWiM 68: The fungus among us

tested surfacesHosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt and Michele Swanson.

Vincent, Elio, Michael, and Michele discuss the amazingly high level of intergenera gene exchange among haloarchaea in an Antarctic lake, and the diversity of fungi on residential surfaces and the human forehead.

Right click to download TWiM #68 (51 MB .mp3, 71 minutes).

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TWiM 67: Black mushrooms and RNA thermosensors

auricularia auricula-judaeHosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt

Vincent, Elio, and Michael discuss how temperature triggers Neisseria menigitidis immune evasion, and protection of mice from ionizing radiation by feeding them black mushrooms.

Right click to download TWiM #67 (55 MB .mp3, 75.5 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

Send your microbiology questions and comments to [email protected]

TWiM 66: The shape of a container

outer membrane vesiclesHosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt and Michele Swanson

Vincent, Elio, Michael, and Michele discuss the curious outer membrane vesicles of Neisseria meningitidis, and sources of Clostridium difficile infection revealed by genome sequencing.

Right click to download TWiM #66 (50 MB .mp3, 68 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

Send your microbiology questions and comments to [email protected]

The Hosts of TWiM

Petra Levin, Ph.D.


Michele Swanson, Ph.D.


Michael G. Schmidt, Ph.D.


Vincent Racaniello, Ph.D.


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Please note that content in MicrobeTV podcasts should not be construed as medical advice.