This Week in Microbiology

TWiM 85: Oscillation in the ocean and a Verona integron

August 21, 2014

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson

Vincent, Elio, Michael, and Michele discuss the diel transcriptional rhythms of bacterioplankton communities in the ocean, and extensively drug resistant Pseudomonas in Ohio.

Right click to download TWiM#85 (56 MB .mp3, 77 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode

Risks and benefits of gain-of-function experiments (mBio)
Scientists for Science
Diel transcriptional oscillations in ocean bacteria (Science)
Taking the pulse of ocean microbes (Science)
North Pacific Subtropical Gyre (Wikipedia)
C-MORE program
Cyanobacteria bloom in Toledo (NY Times)
Extensively drug resistant Pseudomonas (AAC)
Antibiotic resistome (EID)
Modified Hodge test (CDC)
Modified Hodge test photo (Flickr)
MBL test (Clin Micr Rev)
Letters read on TWiM 85

Send your microbiology questions and comments to [email protected]

TWiM 84: Microbiology Down Under

August 11, 2014

Host: Vincent Racaniello

Special guests: David McMillan, Melanie Thomson, and Adam Polkinghorn

In Melbourne, Australia Vincent speaks with David, Melanie, and Adam about their work on group A Streptococcus, Helicobacter pylori, and infections of Koalas with Chlamydia.

Right click to download TWiM#84 (50 MB .mp3, 69 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode

Novel Streptococcus pyogenes vaccine candidates (Vaccine)
Helicobacter pylori induces iron deficiency in mice (PLoS One)
IL17A marker for chlamydial disease in koala (Dev Comp Imm)
Video of this episode: view below or at YouTube

Send your microbiology questions and comments to [email protected]

TWiM 83: Illuminating tuberculosis and cryptococcosis

July 24, 2014

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.

Vincent, Michael, Elio and Michele review a new fluorogenic diagnostic test for tuberculosis bacteria, and the role of a metalloprotease in helping a fungus invade the central nervous system.

Right click to download TWiM#83 (57 MB .mp3, 79 minutes)
Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode

Fluorogenic probes for rapid detection of Mycobacterium tuberculosis (Ange Chem)
Fungal protease required for invasion of the central nervous system (mBio)
C. neoformans cryptococcosis (CDC)
Letters read on TWiM 83

Send your microbiology questions and comments to [email protected]

TWiM 82: Betrayal and compromise

July 10, 2014

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson

Vincent, Michael, Elio and Michele discuss how an endosymbiont betrays its aphid host to alert plant defenses, and a new immunosuppressive cell that allows infection of neonates.

Right click to download TWiM#82 (51 MB .mp3, 71 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode

Endosymbiont protein betrays aphid (PNAS)
Plant immune system (Nature)
Plant defenses against pathogens (Am Phyt Soc)
New neonatal defense against infection (Nature)
Marty Blaser and Bill Maher (YouTube)
Two days from any village (YouTube)
Letters read on TWiM 82

Send your microbiology questions and comments to [email protected]

TWiM 81: Cold iron is the master of them all

June 28, 2014

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson

Vincent, Michael, and Michele discuss how iron might disperse bacterial biofilms in carotid arterial plaques, and controlling Salmonella by modulating host iron homeostasis.

Right click to download TWiM#81(49 MB .mp3, 71 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

Biofilm bacteria in carotid arterial plaques
Oral bacteria in carotid plaques (Eur J Clin Invest)
Controlling Salmonella by modulating host iron homeostasis (Nat Med)
Mesenteric lymph nodes (Wikipedia)
TWiV 282: Tamiflu and tenure too
Cold Iron by Rudyard Kipling
Image credit
Letters read on TWiM 81

Send your microbiology questions and comments to [email protected]

TWiM 80: Hurling fleas and designer chromosomes

June 11, 2014

Xenopsylla cheopis Hosts: Vincent Racaniello, Elio Schaechter, and Michele Swanson

Vincent, Elio, and Michele discuss how to synthesize a designer yeast chromosome, and deciphering the genetic changes path that allowed Yersinia pestis to be transmitted by fleas.

Right click to download TWiM#80 (52 MB .mp3, 54 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

Total synthesis of a yeast chromosome (Science)
Evolution of Y. pestis to flea-borne transmission (Cell Host Micr)
Proventricular valve (Wikipedia)
Image: flea with Y. pestis proventricular mass
Letters read on TWiM 80

Send your microbiology questions and comments to [email protected]

TWiM 79: A community of microbiologists

May 29, 2014

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson

Vincent, Michael, and Michele review highlights of the 2014 General Meeting of the American Society for Microbiology in Boston, MA.

Right click to download TWiM#79 (49 MB .mp3, 71 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

ASM General Meeting 2014
ASMCUE
Video of Listeria infection (one, two)
Where pathogens can linger on airplanes (ASMLive)
Coral reef ecosystems lab
TWiV 286: Boston TWiV party
Letters read on TWiM 79

Send your microbiology questions and comments to [email protected]

TWiM 78: A bacterium grows in Brooklyn

May 15, 2014

MacConkey's agar Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt

Vincent, Elio, and Michael consider a fungal pathogen of insects that acquired a gene from its host that facilitates infection, and presence of gram-negative nosocomial pathogens on community surfaces near hospitals in Brooklyn.

Right click to download TWiM#78 (46 MB .mp3, 63 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

An insect gene makes a fungus pathogenic (PLoS Path)
Fungi growing out of insects (one and two)
Community surfaces harbor bacterial pathogens (Am J Inf Cont)
Healthcare-associated infections (NEJM)
Image credit
Letters read on TWiM 78

Send your microbiology questions and comments to [email protected]

TWiM 77: Zombie plants and no pain, no gain

May 1, 2014

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt and Michele Swanson

Vincent, Elio, Michael, and Michelle review how a pathogen promotes plant attractiveness to insect vectors, and activation of sensory neurons that modulate pain and inflammation by bacterial infection.

Right click to download TWiM#77 (49 MB .mp3, 68 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

Phytoplasma effector hijacks plant reproduction (PLoS Biol)
Phyllogen induces phyllody (Plant J)
Hacking aphid behavior (TWiV #70)
Demeanors, moods, and microbes (Microbe)
Bacteria activate sensory neurons to immunomodulate (Nature)
Image credit
Letters read on TWiM 77

Send your microbiology questions and comments to [email protected]

TWiM 76: Genetic biopixels and a pathogenic sweet tooth

April 11, 2014

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt and Michele Swanson

Vincent, Elio, Michael, and Michelle discuss the use of bacteria to build a genetic sensor for heavy metals, and how host sugars help enteric pathogens to expand after antibiotic treatment.

Right click to download TWiM#76 (48 MB .mp3, 67 minutes).

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode:

Sensing array of radically coupled biopixels (Nature)
Synchronized genetic clocks (YouTube)
Synchronization of 32 metronomes (YouTube)
Quorum sensing – Bonnie Bassler (YouTube)
Host sugars help antibiotic-mediated expansion of enteric pathogens (Nature)
Finding a sugary foothold (Cell Host Micr)
Letters read on TWiM 76

Send your microbiology questions and comments to [email protected]

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TWiM 85: Oscillation in the ocean and a Verona integron

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TWiM 84: Microbiology Down Under

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TWiM 83: Illuminating tuberculosis and cryptococcosis

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TWiM 82: Betrayal and compromise

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TWiM 80: Hurling fleas and designer chromosomes

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TWiM 79: A community of microbiologists

Links for this episode:

TWiM 78: A bacterium grows in Brooklyn

Links for this episode:

TWiM 77: Zombie plants and no pain, no gain

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TWiM 76: Genetic biopixels and a pathogenic sweet tooth

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