TWiM 198: Unexpectedly pathogenic bacteriophages

The TWiM team presents an extracellular bacterium associated with Paramecium, and induction of antiviral immunity by a bacteriophage that prevents bacterial clearance.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt

Right click to download TWiM#198 (30 MB .mp3, 60 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 197: Intercellular microbial trade

The Microbials reveal how a chemosynthetic symbiont stores energy for its marine flatworm host, and extraction of nutrients from host cells by E. coli injectisome components.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt

Right click to download TWiM#197 (51 MB .mp3, 70 minutes)

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Links for this episode

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 196: I hear you

The Microbials discuss how ambrosia beetles utilize ethanol to farm fungi, and how cleaved cochlin protein sequesters bacteria in the inner ear to preserve hearing function.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt

Right click to download TWiM#196 (46 MB .mp3, 64 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 195: Gingipain in the Alzheimer brain

Michael and Vincent discuss the finding of immunity to Cas9 protein in humans, and a potential role for an oral bacterium in Alzheimer’s disease.

Hosts: Vincent Racaniello and Michael Schmidt

Right click to download TWiM#195 (36 MB .mp3, 65 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 194: Standard imperial procedure

How a bacterium helps dengue virus replicate in the mosquito gut, and minicells as a damage disposal mechanism in E. coli.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter

Right click to download TWiM#194 (32 MB .mp3, 65 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 193: Persisters

The TWiM team explore how Lactobacillus reuteri can rescue social deficits in three mouse models of autism spectrum disorder, and the role of Salmonella persisters in undermining host defenses during antibiotic treatment.

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter

Right click to download TWiM#193 (29 MB .mp3, 61 minutes)

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Links for this episode

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 192: A Qtip for phages

Armillaria gallica

The TWiM team reveals an extremely low rate of mutation in a 2500 year old, 185 acre fungus in Michigan, and how a host-produced quorum sensing autoinducer controls the phage switch between lysis and lysogeny.

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson

Right click to download TWiM#192 (30 MB .mp3, 62 minutes)

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Links for this episode

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 191: By the pulp of their teeth

tooth-cross-sectionThe TWiM team reveals the oldest human plague from 4,900 years ago in Sweden, and engineering E. coli to become an endosymbiont in yeast, modeling the evolution of mitochondria.

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson

Right click to download TWiM#191 (30 MB .mp3, 62 minutes)

Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

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Links for this episode

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 190: Exosomes in your nose and in your gut

exosomesThe TWiM-opods consider two stories about exosomes, vesicles that are shed from cells: those that eliminate airway pathogens, and those from the plants we eat that shape our gut microbiome.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson

Right click to download TWiM#190 (35 MB .mp3, 71 minutes)

Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

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Links for this episode

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

TWiM 189: Salmonella BonJovi

worlds fungiThe TWiM team considers the state of the world’s fungi as revealed by a report from the Kew Royal Botanical Gardens, and how Salmonella loses motility to evade host defenses.

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson

Right click to download TWiM#189 (35 MB .mp3, 71 minutes)

Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a Patron of TWiM!

Links for this episode

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

About the Hosts of TWiM

Vincent Racaniello, Ph.D. (@profvrr) is Higgins Professor of Microbiology & Immunology at Columbia University Medical Center. He has been studying viruses for over 40 years. He teaches virology to undergraduate and graduate students, as well as medical, dental, and nursing students. His lectures are available online at iTunes University, YouTube, and Coursera.


Michael Schmidt, Ph.D. (TWiM) is the Professor and Vice Chairman of Microbiology and Immunology and Director of the Office of Special Programs at the Medical College of South Carolina. Dr. Schmidt is leading a team of infectious disease specialists from three health sciences centers and engineers from industry.

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