The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work.
Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer
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Download Immune 4 (51 MB .mp3, 83 min)
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Links for this episode
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- Synthetic Immunoreceptors for Cancer Therapy (Trend Mol Med) 17:27
- Engineering immune cells to treat cancer (Cell) 44:05
- Engineering T cells for fungal infections (PNAS) 50:16
- CAR T cells for AIDS (PLoS Path) 51:10
- CAR T cells (NIH) 20:04, 29:46
- Transcript of this episode (html, pdf)
- Image credit
- Letters read on Immune #4 1:05:59
Weekly Science Picks 1:15:15
Cindy – What’s In A Name?
Steph – Novel Targets
Vincent – Friendly Penguin
Music by Steve Neal. Immune logo image by Blausen Medical.
Send your immunology questions and comments to immune@microbe.tv
Excellent discussion of CAR T Cell Therapy. One of the best I have heard on this topic. Would very much enjoy hearing future shows on the various topics related to this topic that were suggested during the podcast.
Hello Immune Team,
I love this new podcast. I’m a molecular virologist and tend to be a little intimidated by immunology, but you guys do a great job explaining immunology for non-immunologists. I’m teaching immunology this semester as a mostly undergraduate class and I’ve recommended this podcast to them. I even plan to introduce CAR T cells towards the end of the class with a student group presenting a journal article on it so this last episode was great.
So far in class, we’re just finishing up innate immunity and I had a question that I can’t easily figure out. I was hoping someone would be able to help clarify it for me. The textbook I’m using shows a table of the different TLRs, their ligands, microbes recognized, and the cells carrying that TLR. For TLR3 and 8, it states that NK cells are the only cells expressing those receptors. I thought that was odd since they sense viral RNAs and would be more helpful in cells that are infected more frequently by viruses. I started to do a pubmed search to help explain this and found a bunch of articles talking about TLR3 being found in macrophages, dendritic cells, epithelial cells, and NK cells. I also found that TLR3 can sometimes be translocated to the plasma membrane and isn’t exclusively found on endosomes so that was interesting too. That’s when I checked Janeway’s Immunobiology (8th edition) and found the same table, but a paragraph on the next page talking about multiple cell types expressing TLR3. Could someone help clarify the location of TLR3 (and 8) for me? Is this an outdated idea? Are they not normally expressed in other cell types, but can be induced?
Thanks for your help and keep up the good work!
Dear Immune hosts,
This (the CAR-T one) was a beautiful podcast. I have told at least 20 people — scientists or not — to listen to it. The excitement about this magnificent piece of human creativity was palpable in Cynthia’s voice.
I have been listening to TWEVO and TWIM, but IMMUNE is now my favorite. Your podcast is very timely for me: I am an evolutionary genomics guy just moving from academia into immunology research in pharma. I made that transition just when you started airing this podcast. Immunology is fascinating to any biologist, but because I have an evolution/population-genetic background, it sounds even more fascinating given the sheer complexity of this system. The emergence of this system is a puzzle that many evolutionary biologists are drawn to (a podcast on this subject, maybe?)
I also love the two immunologists on the show. I like how Stephanie or Cynthia start explaining fundamentals of a concept, and then slowly unravel more technical details that line up well. Both are great communicators, and Vincent, as in all other podcasts, drives the dialogue really well.
I am wondering if, on the IMMUNE page, you could list a few episodes from other podcasts that are very relevant to this one? I am sure there many papers in microbiology and virology that have direct relevance to immunology.
Vincent, thank you for this and all other of your podcasts.
Yogi