TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:17:45

BrianneThe Milky Way’s Black Hole Comes to Light
KathyRiver dolphins playing with anaconda
RichSmallpox vaccination techniques; from knives and forks to needles and pins
AlanVacuum Tubes: a Modern Aladdin’s Lamp
Vincent Books by Pamela Jane

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:27:50

BrianneBacteria and Me Coloring Book
KathySmarter 3D printing
RichBig Ben Restoring the Worlds Most Famous Clock 2021
Vincent Scientific review articles as antivaccine disinformation

Listener Pick

SuellenYour Fantastic Mind Season 3 Ep 2: Long COVID and Making of a Brain Surgeon (Full Episode)

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants.

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Download TWiV 897 (29 MB .mp3, 48 min)
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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost.

Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld

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Weekly Picks 1:32:48

DicksonToots Thilelemans
AmyLargest comet ever identified
Vincent Scientific review articles as antivaccine disinformation

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:25:29

BrianneApple AirTag
KathyDental art/sculpture/mobile/chandelier
AlanVintage Radio and Communications Museum of Connecticut
Vincent For the Love of Enzymes by Arthur Kornberg

Intro music is by Ronald Jenkees

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Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guests: Kartik Chandran, Denise Haslwanter, and Gorka Lasso Cabrera

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Weekly Picks 1:13:29

DicksonEarth Day and Earth Day History
BrianneXKCD: Family Reunion
Vincent Tokaido: A Journey (DVD)

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Elke Muhlberger, Adam Hume, and Gabor Kemenesi

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Weekly Picks 1:11:01

BrianneAPod Stars and Globules in the Running Chicken Nebula
KathyBioRender Poster Builder
RichThe Sins of Our Fathers: An Expanse Novella (The Expanse) by James S. A. Corey
Vincent Baumgartner Restoration

Listener Pick

JTime, Einstein, and the coolest stuff in the Universe

Intro music is by Ronald Jenkees

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