Host: Vincent Racaniello
Guest: Michael Diamond
Michael Diamond visits the TWiV studio to talk about chikungunya virus and his laboratory’s work on a mouse model of Zika virus, including the recent finding of testicular damage caused by viral replication.
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Download TWiV 414 (50 MB .mp3, 83 min)
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Links for this episode
- Chikungunya virus chronic joint disease caused by adaptive response (J Virol) 11:55
- Mouse model of Zika virus pathogenesis (Cell Host Micr) 37:50
- Zika virus infection during mouse pregnancy (Cell) 36:20
- Zika virus infection damages mouse testes (Nature) 40:25
- Uveitis and Zika virus in tears in mice (Cell Rep) 59:45
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Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 1:35
Register for the 2017 ASM Scientific Writing and Publishing Online Course. 1:21:20
Send your virology questions and comments to [email protected]
I’m sure other people have mentioned this, but Asian macaques commonly used in research (rhesus; Macaca mulatta and cynomolgus Macaca fascicularis) are Old World Monkeys, not New World Monkeys, as mentioned at ~17min in TWIV 414. However this does not discount the differences in viral susceptibility between the two populations. Differences in SIV infection between African (nonsymptomatic) and Asian (clinical immunodeficiency) monkeys are a good example. Nor does it contradict Dr. Diamond’s point that these animals were not native to the region where they were placed.
Love the shows.
Samer Jaber, DVM DACLAM