Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan and Kathy review novel approaches to preventing influenza virus infection.
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Download TWiV 236 (64 MB .mp3, 89 min)
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Links for this episode:
- Ultraprotective influenza vaccine in mice (PNAS)
- Vectored immunoprophylaxis of influenza in mice (Nat Biotech)
- Intranasal antibody gene transfer protects agains influenza (Sci Transl Med)
- Estimating influenza associated deaths (CDC)
- Multistate HAV outbreak (CDC)
- Subscribe to Microbeworld video (YouTube)
- Save podcasting (EFF)
- Letters read on TWiV 236
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Kathy – Meteorites through the ages
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Send your virology questions and comments (email or mp3 file) to twiv@microbe.tv
TWiV 236
10:00 email from Eckard Wimmer (see paper #1)
12:00 recoding amino acids by other nucleotides attenuates polio in mice
13:00 recoding (de-) optimization based on codon pairs
15:40 Alan thinks it takes longer to replicate
24:50 Palese said :
general live virus vaccines are host range mutants.
Just reducing replication doesn’t make good vaccines.
Also one wouldn’t like to have HA-deficient vaccine strains for a flu vaccine.
You want as much HA as possible.
26:30 2nd paper
39:50 3rd paper
48:30 emails,letters
I’m doing a research paper about flu virus and I passed by at this wonderful site. I’ve visited some of the links here and it is really helpful. Thanks so much !
I just wanted to let you know that you have all created another virology addict! I have a lot of fragmented education with no formal accreditation but that is about to change! On Thursday I start class to earn a diploma in BioTechnical research. This will give me the entry level foundation I require to pursue a higher degree and I’ve decided to aim for Virology! Someday I hope to actually earn formal credit for all those YouTube classes I’ve been taking from you online 🙂 Who knows, you may even see my smiling face in NY one day at Columbia U!