Junjie from Jason’s lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome.
TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory.
About the Hosts
Jason Shepherd, Ph.D.
Vivianne Morrison, Ph.D.
Tim Cheung, Ph.D.
Vincent Racaniello, Ph.D.