The TWiM team explores how delivery of an enzyme into competitor cells leads to synthesis of (p)ppApp, depletion of ATP, deregulation of metabolic pathways, and cell death, and a refinement of our typical view of bacterial lag phase as a period of nonreplication.
Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt
Right click to download TWiM#225 (46 MB .mp3, 63 minutes)
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Links for this episode
- Killing competitors by synthesis of (p)ppApp (Nature)
- Lag phase is a dynamic period (J Bact)
- Image credit
- Letters read on TWiM 225
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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Interesting, thanks. According to the CDC’s limited hangout; in 2009, it infected sterile water supply, which I assume is low in nutrients being “sterile water”.. Yet magically ferments into large visible weaponized dark clumps while waiting in its liquid softgel format, sitting so innocently on the shelves for the next buy one get one free sale at your local corner pharmacy. Still leaves one wondering to this day why there was a missing lot of children’s Tylenol from Florida and why Ukraine’s epidemic seemed so similar to the illness this bacterial Tylenol menace caused. Reflux and sleep apnea provides it a convenient entry back into airways and lung tissues causing a necrotic pneumonia that looks similar to a lung cancer tumor on X-ray in both infants and elders. Fairly nasty.
Not all words mean something. The order of words is important. Sometimes words mean one thing in one context and another in some other context. You have lost yourself here. Provide context or don’t, either is fine but communication calls for a certain effort.
This episode touched on 2 very deep problems in biology – apoptosis in bacteria and lag time in bacteria and by association prokaryotes. Some of it is undoubtedly touching you. There is a mystery here but mystery in and of itself does not call for commonality.
I would like to hear more about what you are referencing and how it ties into magic spots or idle time in bacteria. It is possible there is a connection. Please make it.
These are two very interesting papers. Very deep discussions about basic science and life here both in-process and result. Fundamental principles of life are brought nearer to the surface here.
Elio and Michael’s coming to terms on lag time is priceless as us Vincent’s tie back to the basic derivation of virology from the differences between lag time and eclipse in viruses.
Magic spots indeed. Replication interruptus? Very interesting and I’m not quite sure if I have thought about this enough.