TWiEVO 34: You don’t know what you’ve got ‘til it’s PON

August 16, 2018

ManateeNels and Vincent discuss how the loss of an enzyme in marine mammals millions of years ago now makes them at risk for neurotoxicity caused by human-made organophosphorous pesticides.

Hosts: Nels Elde and Vincent Racaniello

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Hey farmer farmer put away the chlor-pyri-fus
I don’t care about spots on my apples
Leave me the manatee and walruses

Science Picks 1:13:56

Nels – New dinosaur discovered in Utah
Vincent – The Song of the Dodo by David Quammen

Music on TWiEVO is performed by Trampled by Turtles

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2 comments on “TWiEVO 34: You don’t know what you’ve got ‘til it’s PON

  1. Nathan Clark Aug 17, 2018

    Thanks for featuring our study on PON1! I enjoyed the episode. I can answer a few of the questions that came up about this interesting enzyme. For starters, PON1 has been extensively studied in humans as well, and we generally have strong protective activity against chlorpyrifos and diazinon. Like you suggested, there are human alleles with differing activities, and so certain individuals are more susceptible. Interestingly, those same alleles are also associated with risk for atherosclerosis. Next, yes, the high dN/dS ratios in the bats and primates are intriguing to us, but we haven’t been able to pin the reason down yet. Any ideas that you or your listeners have would be helpful! I hope all is well in Utah and New York.