In his weekly clinical update, Dr. Griffin discusses how vaccination and vaccine hesitancy affects public health and disease spread in terms of mpox, the first human death from H5N1 in US, why one should not feed their pets raw pet food and the metapneumonia outbreak in China before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, how nirmatrelvir-ritonavir/Paxlovid reduces adverse outcomes of COVID in patients with kidney disease, provides information for Columbia University Irving Medical Center’s long COVID treatment center, SARS-CoV-2 infection affects skin conditions including shingles and if long antiviral treatment affects long COVID.
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Links for this episode
- Mpox vaccination hesitancy, previous immunisation coverage, and vaccination readiness in the African region (eClincial Medicine)
- Global prevalence and correlates of mpox vaccine acceptance and uptake (Communications Medicine)
- First case of new mpox variant in France (Reuters)
- First “Bird flu” death in US (NY Times)
- Emerging threat of H5N1 to human health (NEJM)
- Don’t feed your pets raw food (County of Los Angeles Public Health)
- Oregon, nationwide raw pet food recall (CIRAP)
- Raw cat food avian flu, is this like raw milk? (CIDRAP)
- Human metapneumovirus surging in China (The Guardian)
- Viral video of viral chaos: human metapneumovirus in Chinese hospital (The Economic Times)
- Human metapneumovirus in China (NY Times)
- Acute respiratory infections including human metapneumovirus in northern hemisphere (WHO)
- Waste water scan for 11 pathogens (WastewaterSCan)
- US respiratory virus activity (CDC Respiratory Illnesses)
- Weekly surveillance report: clift notes (CDC FluView)
- RSV: Waste water scan for 11 pathogens (WastewaterSCan)
- RSV-Network (CDC Respiratory Syncytial virus Infection)
- US respiratory virus activity (CDC Respiratory Illnesses)
- Waste water scan for 11 pathogens (WastewaterSCan)
- COVID-19 deaths (CDC)
- COVID-19 national and regional trends (CDC)
- COVID-19 variant tracker (CDC)
- SARS-CoV-2 genomes galore (Nextstrain)
- Where to get pemgarda (Pemgarda)
- EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
- Fusion center near you….if in NY (Prime Fusions)
- CDC Quarantine guidelines (CDC)
- NIH COVID-19 treatment guidelines (NIH)
- Infectious Disease Society guidelines for treatment and management (ID Society)
- Drug interaction checker (University of Liverpool)
- The effect of nirmatrelvir-ritonavir on short- and long-term adverse outcomes from COVID-19 among patients with kidney disease (OFID)
- Paxlovid tied to lower risk of hospital stay, heart problems, death in adults with kidney disease and COVID (CIDRAP)
- Molnupiravir safety and efficacy (JMV)
- Convalescent plasma recommendation for immunocompromised (ID Society)
- What to do when sick with a respiratory virus (CDC)
- When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
- Managing healthcare staffing shortages (CDC)
- Steroids, dexamethasone at the right time (OFID)
- Anticoagulation guidelines (hematology.org)
- Daniel Griffin’s evidence based medical practices for long COVID (OFID)
- Long COVID hotline (Columbia : Columbia University Irving Medical Center)
- Chronic urticaria, vitiligo, alopecia areata, and herpes zoster following COVID-19 infection (Journal of Dermatology)
- Impact of extended-course oral nirmatrelvir/ritonavir in established Long COVID:
- (Communications Medicine)
- Letters read on TWiV 1182
- Dr. Griffin’s COVID treatment summary (pdf)
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
The post TWiV 1182: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.
I just realized I should clarify that I made the cross stitch using a pattern by Alicia Watkins on Etsy.
Thank you so much for a great discussion regarding SEID/ MECFS. It felt like the conversation shifted from ‘is it real’ to ‘what’s causing it, I am curious to know?’.
Sending my very best wishes for your son Dr Vincent with hopes that what he has is not this disease because it is sure not easy to live with this.
Self-diagnosed??? The patients in the study were provided by respected experts in the field? Of course, ME/CFS is heterogeneous…but suggesting that the patients somehow thrust themselves into an Ian Lipkin study seems kind of bizarre…
Agreed, Cort. I was horrified when Dickson said that. As you know I corrected him later but I’m not sure he understand.
Yes, indeed, and thank you for doing that. I wrote my comment as he was speaking and before you corrected him. 🙂
Then Dixon suggests that no cytokine studies are relevant (?). Then he suggests that there because there are wide variety of symptoms associated with this disease – it was an amorphous group. In fact, the patients in this study were required to meet the Canadian Consensus Criteria – yes, a symptomatic definition, by a quite specific one, that requires post-exertional malaise (not just fatigue) be a key factor.
Yes, there is controversy but almost all research studies have used the Fukuda definition until recently when some studies, including this one, have begun using the more restrictive Canadian Consensus Criteria. Thanks for pointing out to Dixon how symptom based diseases are dealt with. You have to start somewhere with these diseases and you do so using symptoms.
The ME/CFS community was upset at the way the IOM was created. Once it was clear that ME/CFS experts were going to be the panel most of the upset disappeared…..
Yes, the diagnostic criteria needs more statistical analysis but most of it was built on statistically based studies. Good luck with your son, Vincent
Vincent, thank you again for presenting the latest on ME/CFS. You are always a champion for this community. I was left feeling quite frustrated by some of your guests’ comments, but I am relieved to see that Cort Johnson was submitting corrections as he listened. I am sure you were frustrated (and “horrified”) by some of the misinformation stated during this podcast, and I know you did your best to clear the misconceptions, but you also had to move on as planned. I believe this situation creates a great teaching moment. Rather than adding comments here where I am uncertain your guests will see them, I drafted a couple of pages of information I’d like shared with them via you, in the hopes that they would read the information. Much of it comes straight from the ME/CFS IOM report, and as scientists I assume they would like to stay informed. I will contact you via Facebook. Thank you, and best wishes for your son. Claudia Goodell, MS