In his weekly clinical update, Dr. Griffin discusses how vaccination and vaccine hesitancy affects public health and disease spread in terms of mpox, the first human death from H5N1 in US, why one should not feed their pets raw pet food and the metapneumonia outbreak in China before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, how nirmatrelvir-ritonavir/Paxlovid reduces adverse outcomes of COVID in patients with kidney disease, provides information for Columbia University Irving Medical Center’s long COVID treatment center, SARS-CoV-2 infection affects skin conditions including shingles and if long antiviral treatment affects long COVID.
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Links for this episode
- Mpox vaccination hesitancy, previous immunisation coverage, and vaccination readiness in the African region (eClincial Medicine)
- Global prevalence and correlates of mpox vaccine acceptance and uptake (Communications Medicine)
- First case of new mpox variant in France (Reuters)
- First “Bird flu” death in US (NY Times)
- Emerging threat of H5N1 to human health (NEJM)
- Don’t feed your pets raw food (County of Los Angeles Public Health)
- Oregon, nationwide raw pet food recall (CIRAP)
- Raw cat food avian flu, is this like raw milk? (CIDRAP)
- Human metapneumovirus surging in China (The Guardian)
- Viral video of viral chaos: human metapneumovirus in Chinese hospital (The Economic Times)
- Human metapneumovirus in China (NY Times)
- Acute respiratory infections including human metapneumovirus in northern hemisphere (WHO)
- Waste water scan for 11 pathogens (WastewaterSCan)
- US respiratory virus activity (CDC Respiratory Illnesses)
- Weekly surveillance report: clift notes (CDC FluView)
- RSV: Waste water scan for 11 pathogens (WastewaterSCan)
- RSV-Network (CDC Respiratory Syncytial virus Infection)
- US respiratory virus activity (CDC Respiratory Illnesses)
- Waste water scan for 11 pathogens (WastewaterSCan)
- COVID-19 deaths (CDC)
- COVID-19 national and regional trends (CDC)
- COVID-19 variant tracker (CDC)
- SARS-CoV-2 genomes galore (Nextstrain)
- Where to get pemgarda (Pemgarda)
- EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
- Fusion center near you….if in NY (Prime Fusions)
- CDC Quarantine guidelines (CDC)
- NIH COVID-19 treatment guidelines (NIH)
- Infectious Disease Society guidelines for treatment and management (ID Society)
- Drug interaction checker (University of Liverpool)
- The effect of nirmatrelvir-ritonavir on short- and long-term adverse outcomes from COVID-19 among patients with kidney disease (OFID)
- Paxlovid tied to lower risk of hospital stay, heart problems, death in adults with kidney disease and COVID (CIDRAP)
- Molnupiravir safety and efficacy (JMV)
- Convalescent plasma recommendation for immunocompromised (ID Society)
- What to do when sick with a respiratory virus (CDC)
- When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
- Managing healthcare staffing shortages (CDC)
- Steroids, dexamethasone at the right time (OFID)
- Anticoagulation guidelines (hematology.org)
- Daniel Griffin’s evidence based medical practices for long COVID (OFID)
- Long COVID hotline (Columbia : Columbia University Irving Medical Center)
- Chronic urticaria, vitiligo, alopecia areata, and herpes zoster following COVID-19 infection (Journal of Dermatology)
- Impact of extended-course oral nirmatrelvir/ritonavir in established Long COVID:
- (Communications Medicine)
- Letters read on TWiV 1182
- Dr. Griffin’s COVID treatment summary (pdf)
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
The post TWiV 1182: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.
Two intesesting links:
Peter Jahrling:
“I want to know if this virus is intrinsically different from the one we have seen before, if it is a more virulent strain. We are using tests now that weren’t using in the past, but there seems to be a belief that the virus load is higher in these patients [today] than what we have seen before. If true, that’s a very different bug. ”
http://www.vox.com/2014/10/13/6959087/ebola-outbreak-virus-mutated-airborne
Professor Les Roberts, Columbia University, in Sierra Leone working with the WHO response to Ebola.
“Today we likely do not have ½ the beds in country that we need for the existing cases. I expect that we can triple the treatment beds in the next two months while I am here….and all modeling, even best case scenarios suggest, we will be even further behind the patient bed demand than we are now.”
“Thus, the numbers that you hear about new cases today reflect the transmission dynamics from over 2 weeks ago…..and we thought the doubling time of the outbreak was 30 days, it seems to be less than that here. We knew the ~350 confirmed cases last week were an undercount….we now think there are 7-900 in reality. The need for hospital beds is climbing more than the ability to get them up and running. There might be 200ish ebola treatment beds now countrywide. There are perhaps 600 more in “holding areas.” We have schemes to get 500 or 600 ebola treatment beds up and running over the next 8 weeks. As Foreign Medical Team Coordinator, helping to get these beds up and supported is one of my primary tasks. If there are really 3000 cases this month, and 6000 next month…with all going perfectly on the treatment bed establishment side, we will have 30% of the beds we need next month, slightly worse than the situation now.”
http://pfmhcolumbia.wordpress.com/
Jahrling: “There seems to be a belief”. Last time I heard, beliefs are not what drive science; it’s data. It really bothers me when scientists speak like this, because the press does not know how to deal with it.
Regarding sexual transmission from survivors. Alleged case:
http://awoko.org/2014/10/13/sierra-leone-news-ebola-survivor-infects-wife-to-death/
You probably should remove that “You can’t get Ebola through air” “Facts” box/icon above (top left) since droplet transmission is possible through air…it’s a stretch when conversational English can incorrectly be force-parsed into epidemiological English. Just lose it. And it may be wrong in any case since there is some possibility of aerosol transmission of Ebola in confined places with freshly aerosolized particles being generated. These apparently can potentially remain infective for about 100+ minutes.
Thanks for the topics on arthropods and domestic animals. We may need to deal with pig infections both domestic and wild if a widespread outbreaks including countryside eventuate. We do not need a permanent new disease-animal reservoir. Love the podcast.
It’s not an airborne pathogen. We’ve beaten that issue to death already.
We did discuss the definitions of ‘airborne’ on previous TWiVs, also on Transmission of Ebola virus. Droplet transmission is not defined as airborne, it is a form of contact.
This is a parody, right?
It would be interesting for you to comment Michael Osterholm, (Director of the Center for Infectious Disease Research and Policy) talk about Ebola. https://www.youtube.com/watch?v=UkMKUa0sxBQ&feature=youtu.be
What was the Twitter feed mentioned in this episode? I believe it had the word ‘diversity’ in the name, and was described as a research group.