TWiV 1124: Clinical update with Dr. Daniel Griffin

June 22, 2024

In his weekly clinical update, Dr. Griffin reviews the recent statistics on SARS-CoV-2 infection, before discussing methods for sterilizing filtering facepieces, an update to the fall COVID boosters, the emergency use application of a pre-exposure prophylactic and where to find it and drug interaction database, convalescent plasma, the effectiveness of the monoclonal antibody sotrovimab against Omicron variants, what to do when healthcare workers succumb to SARS-CoV-2 infection, the need for better nursing resources, how survivors of COVID-19-associated ARDS exhibited sustained elevation in endothelial dysfunction biomarkers, correlating with the severity of impaired gas exchange, reactivation of latent CMV as a consequence of a SARS-CoV-2 infection, identification of variables that might impact or predict a person’s time to recovery from an acute SARS-CoV-2 infection and if COVID-19 patients really have olfactory dysfunction more often than normally smelling individuals.

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Links for this episode

COVID-19 national trend (CDC)

COVID-19 deaths (CDC)

Comparison of methods for sterilizing filtering facepiece respirators (American Journal of Infection Control)

Booster update already! KP.2 of JN.1-lineage (FDA)

EUA for pemgarda (FDA)

Where to get pemgarda (Pemgarda)

CDC Quarantine guidelines (CDC)

Early phase of SARs-CoV-2 infection (

NIH COVID-19 treatment guidelines (NIH)

Infectious Disease Society guidelines for treatment and management (ID Society)

Drug interaction checker (University of Liverpool)

Molnupiravir safety and efficacy (JMV)

Convalescent plasma recommendation for immunocompromised (ID Society)

Revisiting monoclonal antibody therapy, sotrovimab for treatment during Omicron BA.2 and BA.5 (Infection)

What do when your healthcare provider is infected with SARS-CoV-2 (CDC)

Managing healthcare staffing shortages (CDC)

Steroids,dexamethasone at the right time (OFID)

Anticoagulation guidelines (

Hospital nurse staffing variation & COVID-19 (International Journal of Nursing Studies)

Endothelial dysfunction and persistent inflammation severe post-COVID-19 (BMC Medicine)

Prevalence and risk for CMV reaction due to COVID-19 pneumonia (PLoS One)

Variables that impact recovery from acute SARS-CoV-2 infetion (JAMA Network Open)

Reduced olfactory bulb volume with dysfunction after mild SARS-CoV-2 inction (Scientific Reports)

Contribute to our Floating Doctors fundraiser

Letters read on TWiV 1124

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to

The post TWiV 1124: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.

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0 comments on “TWiV 1124: Clinical update with Dr. Daniel Griffin

  1. Jayshiv_r Jan 27, 2011

    1st time listener…great topics. draw backs = it sounds like the VIEW. Just cut the chase & talk about science. we don’t want to hear about your videocasts ideas, etc..

    • I beg to disagree with Jayshiv_r; part of what makes the show enjoyable to me is the free banter and off-topic asides! As the hosts often state, it really is a good discussion between knowledgable friends – and the beauty is that it really IS a free discussion, no staging and no rehearsal. Many deeply felt thanks to the hosts!!