TWiV 1103: Jason ‘Spike’ McLellan

April 7, 2024

Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jason McLellan

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Download TWiV 1003 (47 MB .mp3, 65 min)
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Links for this episode

MicrobeTV Discord Server

MicrobeTV store at Cafepress

Become a member of ASV (

The New City by Dickson Despommier

Prefusion-stabilized SARS-CoV-2 spikes (Science)

Structure-based vaccine design (Curr Opin Immunol)

Prefusion-stabilized SARS-CoV-2 S2-only antigen (Nat Comm)

Stabilized coronavirus spike stem elicits broadly protective antibody (Cell Rep)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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The post TWiV 1103: Jason ‘Spike’ McLellan first appeared on This Week in Virology.

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