There’s some work using the olfactory bulb:
Sheep’s mucosa shows the way to more effective medicine for severe neurological diseases
This does not seem to be the case with recreational drug use where cocaine ” is absorbed through the mucous membranes lining the nose and sinuses.”
Response of mice to aerosolized rabies virus. One mouse exposed to Efv1 and 1 mouse exposed to Lnv developed signs of rabies 17 and 8 days after aerosol exposure, respectively. Two mice exposed to Tbv developed signs of rabies, at 10 and 14 days after aerosol exposure. All 4 mice were killed and found to be rabies positive by the DFA . The 5 surviving mice developed anti-rabies VNA (figure 2 ). At ∼5 months after aerosol exposure, the remaining mouse exposed to Tbv died of unknown causes.
Might one presume that the olfactory bulb is an easy to reach portal to the brain for aerosolized rabies?
Hi Dr. Racaniello.
I hope this makes it to a snippet, and I’m sure it will make Dr. Condit intrigued to share his experience with us.
A case report of cowpox infection in human, likely delivered by a cat!
I wanted to bring to your attention a recent publication, authored by Grieg F. Steward and myself, that describes an interesting virus that encodes fermentation genes, titled:
“A giant virus infecting green algae encodes key fermentation genes”
The article is open access and can be downloaded from ScienceDirect at:
Thanks for your great work every week.
Regarding viral piRNAs in other animals, this pre-print of ours might be of some interest: https://www.biorxiv.org/content/early/2017/07/21/166488
Don’t EVEome without it IS the episode with piRNAs https://www.microbe.tv/twiv/twiv-482/
https://www.ncbi.nlm.nih.gov/pubmed/29129531 Andino paper
I’ve sent these links to Rich and he suggested that I should send them to you/TWIV.
I don’t know if you’ve seen these papers that appeared in mSphere about the horsepox synthesis.
Congratulations to the TWIV team. I really enjoyed TWIV 478!
Here is Mike Imperiale (Editor)’s commentary on why mSphere is doing
Here is Greg Koblentz’ article: https://urldefense.proofpoint.com/v2/url?u=http-3A__msphere.asm.org_content_3_2_e00040-2D18&d=DwIFaQ&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=wsY6vpVeaEZKU-0bw-bMSg&m=d7GmYueV5cPI0-jU3lNNxBgzsZRpb2Rur6zmnPuzpvA&s=kC12Kec3i01Ktp3Dz1tX_qhPvqsUOQk0zt3Gg60lNlg&e=
Clarissa Damaso, Ph.D.
Lab. Biologia Molecular de Virus
Instituto de Biofisica Carlos Chagas Filho
Universidade Federal do Rio de Janeiro
Rio de Janeiro, RJ
Hello TWiV Team!
I adore your podcast, and the related podcasts TWiP, TWiEVO, and TWiM! I can’t emphasize enough how helpful it is to have current research and scientific events put into perspective by such knowledgeable experts. As a graduate student in a disease ecology lab, I find these podcasts an invaluable resource. I wish I had discovered them sooner, but at least it will be a very long time before I run out of quality educational entertainment!
Keep up the great work!
Dear TWIV podcasters,
I recently read that our layer of dead skin protects against viruses since they can’t interact with dead cells. So is there evidence that people that actively remove dead skin by exfoliation (e.g. with pumice stones) are more susceptible to viral infections?
-Ken from Oxford