Susan writes:

Hi Dr. Griffin – 

Have you seen an increase in NTM, MAC, and Bronchectiasis since COVID-19? I am a 65-year-old female who has had all of my vaccinations and COVID-19 twice. I have also had another respiratory virus that wasn’t identified. I have recently been diagnosed with NTM, Mac, and Bronchectiasis. 

Thank you for all the information you provide each week to keep us informed.

Susan

Charles writes:

Hello Doctors;

I saw this today and it fit with my previous two emails, so I am sending the link:

https://www.medpagetoday.com/special-reports/features/112871

I really would like to understand why the IDSA Guidelines on the Treatment and Management of Patients with COVID-19 has the following:

Nirmatrelvir/Ritonavir: Conditional recommendation†, Low certainty of evidence

Remdesivir: Conditional recommendation†, Low certainty of evidence

or: Conditional recommendation†, Moderate certainty of evidence

depending on conditions with the patient.

Molnupiravir: Conditional recommendation†, Low certainty of evidence

Convalescent Plasma immunocompromised patients:

Conditional recommendation, very low certainty of evidence:

†The guideline panel concluded that the desirable effects outweigh the undesirable effects, though uncertainty still exists, and most informed people would choose the suggested course of action, while a substantial number would not.

I am a computer programmer, not an MD. When I look at the evidence for the first 3, I do not see a low certainty of evidence.  In the large well run (ie, treatment given early) studies, I see a high certainty of evidence.  What do I have wrong or why is the IDSA being so conservative?

Thanks,

Charles

Lis writes:

Could Daniel add the required reporting data that starts Nov 1  to Clinical Updates. (See below)Thanks for all you do. 

Lis

Mike writes:

Hi Daniel,

Given the MNRA vaccines don’t seem so durable, is there a possibility the J&J actually wasn’t as ineffective as people thought if it had been compared over a longer time period? Are there any studies on this?

Mike (who got a J&J vaccine and had all his friends make fun of him)

Hat writes:

Quick Question:

Should we be treating Asymptomatic Congenital Hepatitis B Patients with Etecavir/Tenofovir to delay onset of liver disease a/o cancer?

Thanks

Connie writes:

Daniel and Vincent,

Thank you for your invaluable show, which has gotten me through Covid !  

Do you have any information on what steps the government or industry are taking in developing a vaccine for the avian flu ?  It doesn’t seem far-fetched that the virus will mutate to be dangerous to humans.  Could the mortality rate really be 50 % ?  

Thanks,

Connie