Justin writes:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10089217
Daniel, is this actually a thing? Namely, there are people can stop ART and yet maintain low viral load?
Reason I ask is (believe it or not) there are a substantial amount of people online that totally deny the existence of viruses at all (wild but true) are they are pointing to personal testimonials from people who have stopped ART, and well….you can see where this is going. In effect they are telling people “nobody needs ART” which is absolute insane/dangerous.
One example of the insanity:
https://controlstudies.substack.com/p/nodrugsneeded
Justin
Marshall writes:
Dear Daniel, dear Vincent,
First, let me say that I felt your podcast was incredibly important during the pandemic. However, maybe it’s even more important now in the current political situation.
Listening to the last clinical update and the latest TWIV. I wanted to provide some context for the latest Moderna vaccine approval. To be clear, my understanding is that the new Moderna vaccine is approved in addition to their previous vaccine. The newly approved vaccine would also likely have to be updated for strain specific substitutions in the sequence of spike on a yearly basis even tough I understand the trial was done with BA4/5. But, this is not yet entirely clear to me. The new vaccine encodes, a significantly shorter spike protein than Spikevax, which includes a portion of the N-terminal domain and the receptor binding domain, as well as a heterologous transmembrane domain, but it lacks lacks the S2 domain (meaning there need not be the stabilizing proline substitutions). This allows for a much shorter mRNA encoding the antigen, and therefore a lower dose can be used, apparently resulting in less reactogenicity.
I just thought I’d weigh-in since it did not seem clear from the previous episodes what the new vaccine entailed.
Love discussions and I will continue to listen and support you! Keep up the good work.
Best,
Marshall
Colleen writes:
Hello Dr. Griffin
I just wanted to firstly THANK YOU for being such a wonderful compassionate doctor . I know you aren’t seeing long covid patients anymore, but I credit you for the improvement of my quality of life that I have gotten back! Still a long way to go but I see hope!!
Here’s my question which I am not sure if you would know the answer to this or maybe I am just crazy and this is coincidental. But I feel compelled to tell you this possibly interesting correlation. So last Pemgarda infusion was 10/20/2024, and after I was able to eat food again and digest it …(thought it was probably the bifidobacterium probiotics)
then I was due for another infusion in January- wasn’t able to receive it and began having the severe diarrhea again but it became severe again by Feb /March and was multiple times a day every single day, I was completely unable to eat solid food again without severe symptoms after,that continued every day. THEN 6/2/2025 I received Pemgarda infusion ( insurance finally resolved) and about two days later I was able to eat a turkey club sandwich!! I actually ate 4 of them. I have eaten solid food every day since, without severe diarrhea afterwards . I even gained a few pounds . I’m just thinking is there any way this is correlation? I know it’s only been a few days but I had not gone one day without that severe symptom after eating. Maybe it’s coincidence, maybe I’m just crazy ! But I thought you’d find it really interesting and maybe there is some mechanism….
Thanks again! And I will always be grateful that you helped me more than you know !
Also I can’t wait for America to be SANE AGAIN – thank you for you and twiv team for helping us at least stay informed throughout this terrible time.
Colleen
Daina writes:
Hi Daniel and Vincent,
I’m listening to clinical update this morning and have a correction for you.
While FDA approved Moderna’s mNEXSPIKE vaccine based on the non-inferiority trial versus SPIKEVAX, Moderna still has to do the randomized superiority trial versus saline in adults 50-64 at low risk. Read the full FDA letter to see the post marketing commitments.
https://www.fda.gov/media/186740/download?attachment
Daina
Steve writes:
I recently contracted covid on a trip to Sitka Alaska by ferry. After I tested positive, I had a conference call with my family physician and she prescribed Paxlovid and also a Rx called Metformin for two weeks. She said the Metformin may help to prevent long Covid. I’ve listen weekly to TWIV with Dr. Griffin but have never heard any mention of Metformin. What can you tell me about it? Is it worth taking? Are there downsides? This is my second bought of covid and it’s been almost 4 weeks and I’m still not fully over it. Nasty bug. Thank you.
Steve
Coeur d’Alene Idaho.