Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
The TWiPsters solve the case of the Peace Corps Volunteer with a Liver Lesion, and discuss the dependence of Leishmania survival on the gut microbiome of the sandfly.
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Download TWiP #127 (49 MB .mp3, 80 minutes)
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Links for this episode:
- Leishmania depends on sandfly gut microbiome (mBio)
- Kava (Wikipedia)
- Letters read on TWiP 127
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Case Study for TWiP 127
The last of our trio for the Peace Corp, an eosinophilia case. 29 yo pc volunteer in Rwanda, male, 3 weeks of feeling poorly. Starts with rash on lower back and upper legs, maculopapular rash. Fatigue later, cough, then diarrhea, 51% eosinophils (9000). No significant exposure to fresh water. Stool sent for oandp. Said sat down and got something on behind, realized later was feces, this was where rash developed. OandP seeing larva in stool. HIV neg, no med issue, no surgeries, no Kava.
Send your case diagnosis, questions and comments to twip@microbe.tv
Music by Ronald Jenkees
Good day My guess for the patient in 127 is Hook worm. Was wavering between Hook worm and S. stercoralis because of where he was infected, Rwanda and the presence of monkey who are a reservoir host however, the presence of “fresh” feces would suggest that the S.stercoralis would still be free-living rather than parasitic and the high number of larvae would also point to hook worm.
Thank you for your very informative podcaste
Dave the sheep shearer from southern Alberta Canada, where it’s currently 3c and calm. I’m slowly working through your early pods. Up to 24 now and listening to each 2 or 3 times( feeling very parasitic as I’m trying to extract as much knowledge as possible before molting and moving on to the next stage)
I love TWiP. Hoping for #14