Mark O Martin is TWiM-adjacent for this discussion of a Fusobacterium nucleatum clade that dominates colorectal cancer, and surface colonization by Flavobacterium johnsoniae promotes its survival in a model microbial community.
TWiM reviews a case of E. faecium bacteremia treated with combination bacteriophage and antibiotic therapy, and how dopamine receptor D2 confers colonization resistance via microbial metabolites.
TWiM discusses the identification of natural products from reconstructed ancient bacterial genomes, and how plant mRNAs move into a fungal pathogen via extracellular vesicles to reduce infection.
TWiM reviews the ongoing cholera outbreak in Africa, and research showing that gut complement induced by the microbiota blocks pathogens and spares commensal bacteria.
TWiM reveals a new population in the blue cheese-making fungus Penicillium roqueforti and identification of a quorum-sensing autoinducer and siderophore in uropathogenic Escherichia coli.
TWiM reveals a database of genome sequences of thousands of Mycobaterium tuberculosis, allowing association with resistance phenotypes to 13 antibiotics, and microbe-derived uremic solutes that enhance thrombosis potential in the host.
TWiM describes the mechanism for the S. aureus itch and scratch induced skin damage, and discovery of a novel class of antibiotics that targets the lipopolysaccharide transporter.
A highly reduced TWiM team presents a study of the use of phage diversity in cell-free DNA to identify bacterial pathogens in human sepsis cases, and the evolution, persistence, and host adaptation of a gonococcal antimicrobial resistance plasmid that emerged in the pre-antibiotic era.
On the occasion of TWiM’s 300th episode, we discuss how two college students found a new antibiotic in soil, Barbara Iglewski’s passing, and Elio returns for an appearance.
From ASM’s Conference for Undergraduate Educators 2023 in Phoenix, TWiM speaks with Amaya Garcia Costas and Gwendolyn Knapp about their approaches to undergraduate microbiology education, and how they use TWiM as part of their curricula.
About the Hosts of TWiM
Vincent Racaniello, Ph.D. (@profvrr) is Higgins Professor of Microbiology & Immunology at Columbia University Medical Center. He has been studying viruses for over 40 years. He teaches virology to undergraduate and graduate students, as well as medical, dental, and nursing students. His lectures are available online at iTunes University, YouTube, and Coursera.
Michael Schmidt, Ph.D. (TWiM) is the Professor and Vice Chairman of Microbiology and Immunology and Director of the Office of Special Programs at the Medical College of South Carolina. Dr. Schmidt is leading a team of infectious disease specialists from three health sciences centers and engineers from industry.