Mark O Martin is TWiM-adjacent for this discussion of a Fusobacterium nucleatum clade that dominates colorectal cancer, and surface colonization by Flavobacterium johnsoniae promotes its survival in a model microbial community.
TWiM describes a potential connection between a bacterial protein that damages DNA and human cancers, and how to synthesize antimiicrobial natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic.
TWiM reviews aspirin modulation of Fusobacterium nucleatum, a microbe that has been associated with colorectal cancer, and Elio tells us ‘What are vaccines’, a talk he recently gave to members of his community.
The Fellowship of the TWiM reveal that colorectal cancer-associated microbiota are associated with higher numbers of methylated genes in colonic mucosa, and identification of metabolites needed by the fire blight disease bacterium for virulence in apples.
The TWiM team explores a stingless bee that requires a fungal steroid to pupate, and colonic biofilms containing tumorigenic bacteria in patients with colorectal polyps.
The TWiM team focuses on the gut microbiome, from a single member, Akkermansia muciniphila, to the effect of antibiotics on its composition and colonization resistance against C. difficile.
Vincent, Michael, and Michele explain how the gut microbiome modulates colon tumorigenesis, and regulation of intestinal macrophage function by the microbial metabolite butyrate.
About the Hosts of TWiM
Vincent Racaniello, Ph.D. (@profvrr) is Higgins Professor of Microbiology & Immunology at Columbia University Medical Center. He has been studying viruses for over 40 years. He teaches virology to undergraduate and graduate students, as well as medical, dental, and nursing students. His lectures are available online at iTunes University, YouTube, and Coursera.
Michael Schmidt, Ph.D. (TWiM) is the Professor and Vice Chairman of Microbiology and Immunology and Director of the Office of Special Programs at the Medical College of South Carolina. Dr. Schmidt is leading a team of infectious disease specialists from three health sciences centers and engineers from industry.