TWiV reviews influenza H5N1 in North American cows and in birds throughout New York City, polio health emergency extended, ChatGPT to control vaccine hesitancy, increasing viral hepatitis worldwide, dengue public health alert in Puerto Rico, cherry trees drowning in Washington DC, death of iron lung Paul, origin and dispersal history of hepatitis B virus in Eastern Eurasia, and antibody-independent protection against heterologous SARS-CoV-2 challenge.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Download TWiV 1105 (76 MB .mp3, 106 min)
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MicrobeTV Discord Server

MicrobeTV store at Cafepress

Become a member of ASV (asv.org)

The New City by Dickson Despommier (blog post)

Navigating the U.S. Immigration System webinar

International Conferene on Pandemic Preparedness

Avian influenza in dairy cows North Carolina and South Dakota

H5N1 clade 2.3.4.4 Pathogenic flu throughout NYC

Polio from Afghanistan to Pakistan extending public health emergency

CHAT GPT to combat vaccine hesitancy

Viral hepatitis worldwide

Dengue public health alert in Puerto Rico

Cherry trees being drowned by water level rise in DC

Paul in iron lung dies (NPR)

Hepatitis B virus in Eastern Eurasia (Nat Comm)

Antibody-independent protection against heterologous SARS-CoV-2 (Nature)

Timestamps by Jolene. Thanks!

Weekly Picks

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VincentThe Scientists Rock. Literally.

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

The post TWiV 1105: All the T and B in China first appeared on This Week in Virology.

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles before addressing results of Pfizer’s phase 3 RSV vaccine clinical trial for adults under 60, RSV, influenza and SARS-CoV-2 circulation, differences between rural and urban communities dealing with SARS-CoV-2 infections, the latest statistics on influenza and COVID-19 circulation, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how long COVID affects the brain and associates with an increase in allergic incidents as well as if post SARS-CoV-2 infected patients are unable to exercise or have functional limitations. For more information about this body of work, listen to TWiV 1088.

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Measles tracking (CDC)

Measles just this year (MMWR)

ABRYSVO phase 3 results (Pfizer)

RSV surveillance (CDC)

Influenza/flu surveillance  (CDC)

Provisional deaths due to COVID-19 (CDC)

COVID-19 national trend (CDC)

COVID-19 wastewater testing (biobot)

Variant tracker (CDC)

Rural-urban differences in COVID-19 mortality and hospitalizations (OFID)

Spring COVID-19 booster recommendations (CIDRAP)

Older adult spring booster available (CDC)

Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC)

EUA for pemgarda (FDA)

CDC Quarantine guidelines (CDC)

NIH COVID-19 treatment guidelines (NIH)

Nirmatrelvir for vaccinated or unvaccinated COVID-19 patients (NEJM)

Assessment for clinical usefulness (NEJM)

Molnupiravir safety and efficacy (JMV)

Convalescent plasma recommendation for immunocompromised (IDSociety)

Updated respiratory virus guidances (CDC)

What do when your heathcare provider is infected with SARS-CoV-2 (CDC)

Managing healthcare staffing shortages (CDC)

Steroids,dexamethasone at the right time (OFID)

Anticoagulation guidelines (hematology.org)

Long COVID evidence based review TWiV shout out (TWiV 1088)

Brian and cognitive changes in long COVID patients (BRAIN)

Allergic disease incidents after COVID-19 (Nat Comm)

Can post COVID patients exercise or do they have functional limitations (JAMA Network Open)

Contribute to our ASTMH fundraiser at PWB 37:06

Letters read on TWiV 1102 37:56

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The post TWiV 1104: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.

Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jason McLellan

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The New City by Dickson Despommier

Prefusion-stabilized SARS-CoV-2 spikes (Science)

Structure-based vaccine design (Curr Opin Immunol)

Prefusion-stabilized SARS-CoV-2 S2-only antigen (Nat Comm)

Stabilized coronavirus spike stem elicits broadly protective antibody (Cell Rep)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

The post TWiV 1103: Jason ‘Spike’ McLellan first appeared on This Week in Virology.

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles and influenza before addressing Vincent’s comment on measles inclusion in the clinical respiratory PCR panel, the latest statistics on influenza and COVID-19 circulation, if inflammatory cytokines and anti-viral antibody function synergistically, if administration of peptide agonists of the glucagon-like or sodium-glucose pump can reduce disease severity, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines for SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir or paxlovid can reduce cardiovascular adverse events and the first finding of the two-year longitudinal study on long COVID. For more information about this body of work, listen to TWiV 1088.

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Download TWiV 1102 (36 MB .mp3, 49 min)
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Measles tracking (CDC)

What happens when measles is included in commercial syndromic PCR panels (MMWR)

Influenza/flu surveillance (CDC)

Influenza on the Texas ranch (Statnews)

Sequence analysis of highly pathogenic avian influenza from Texas (CDC)

Influenza/flu map (CDC)

COVID-19  hospital admissions (CDC)

COVID-19 national trend (CDC)

COVID-19 wastewater testing (biobot)

Variant tracker (CDC)

Variant hospital admissions (CDC)

Can inflammatory cytokines and antibodies play nicely to prevent COVID-19 mortality (IJID)

Association of GLP-1RA and SGLT-2i to modulate COVID-19 severity (Diabetes Therapy)

Spring COVID-19 booster recommendations (CIDRAP)

Older adult spring booster available (CDC)

Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC)

EUA for pemgarda (FDA)

CDC Quarantine guidelines (CDC)

NIH COVID-19 treatment guidelines (NIH)

Molnupiravir safety and efficacy (JMV)

Convalescent plasma recommendation for immunocompromised (IDSociety)

CDC Quarantine guidelines (CDC)

NIH COVID-19 treatment guidelines (NIH)

What do when your heathcare provider is infected with SARS-CoV-2 (CDC)

Managing healthcare staffing shortages (CDC)

Steroids,dexamethasone at the right time (OFID)

Anticoagulation guidelines (hematology.org)

Remdesivir and cardiac adverse events in hospitalized patients (CID)

Long COVID evidence based review TWiV shout out (TWiV 1088)

Longitudinal study reveals long COVID symptom peaks and nadirs (OFID)

Paxlovid lowers risk of cardiovascular disease in COVID-19 patients with autoimmune disease (BMC Medicine)

Contribute to our ASTMH fundraiser at PWB

Letters read on TWiV 1102

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The post TWiV 1102: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.

Paul Offit joins TWiV to discuss his latest book, “Tell Me When It’s Over”, an insider’s guide to deciphering COVID myths and navigating our post-pandemic world.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guest: Paul Offit

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The New City by Dickson Despommier

Tell Me When It’s Over by Paul Offit

Navigating the U.S. Immigration System (webinar)

Classifying Viral Subspecies (Workshop)

Options XII for the Control of Influenza (Meeting)

Letters read on TWiV 1101

Timestamps by Jolene. Thanks!

Weekly Picks

DicksonAstronomers Unveil Strong Magnetic Fields Spiraling at the Edge of Milky Way’s Central Black Hole
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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

The post TWiV 1101: It’s not over ’til it’s Offit first appeared on This Week in Virology.

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles influenza and SARS-CoV-2, before discussing the development of new monoclonal antibody therapy, if vaccines and antivial drugs can used effectively together. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound including that after administration of the “oral remdesivir”, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if one can predict the loss infectivity of healthcare workers with mild COVID-19 disease and the dynamics of household transmission of the virus in children.

Click arrow to play
Download TWiV 1100 (32 MB .mp3, 44 min)
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Links for this episode

Measles tracking (CDC)

Influenza/flu surveillance  (CDC)

Influenza/flu map (CDC)

COVID-19  hospital admissions (CDC)

COVID-19 national trend (CDC)

COVID-19 wastewater testing (biobot)

Variant tracker (CDC)

Variant hospital admissions (CDC)

What new monoclonal antibody therapy? (FDA)

A New pre-exposure prophylaxis for COVID-19? (Invivyd)

CDC Quarantine guidelines (CDC)

NIH COVID-19 treatment guidelines (NIH)

Really COVID-19 rebound after Nirmatrelvir-ritonavir treatment? (JAMA Network Open)

Can vaccines and antiviral be effective for COVID-19 together (International Journal of Infectious Diseases)

Molnupiravir safety and efficacy (JMV)

Convalescent plasma recommendation for immunocompromised (IDSociety)

CDC Quarantine guidelines (CDC)

NIH COVID-19 treatment guidelines (NIH)

What do when your heathcare provider is infected with SARS-CoV-2 (CDC)

Managing healthcare staffing shortages (CDC)

Can loss of infectivity among healthcare works with mild and recurrent COVID-19 be predicted (CID)

Household transmission dynamics in children with asymptomatic infection (CID)

Steroids,dexamethasone at the right time (OFID)Anticoagulation guidelines (hematology.org)

Contribute to our ASTMH fundraiser at PWB

Letters read on TWiV 1100

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The post TWiV 1100: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.

Vincent travels to the University of Heidelberg to speak with Volker Lohmann about his career and the research of his laboratory on hepatitis C virus, hepatitis A virus, and norovirus.

Host: Vincent Racaniello

Guests: Volker Lohmann

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The New City by Dickson Despommier

HCV human challenge studies (Lancet Gastro Hepatol) 51:25

Comparison of HCV and HAV infections (J Hepatol) 33:41

HCV cell culture systems (J Med Chem)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

The post TWiV 1099: Volker Lohmann, as persistent as his viruses first appeared on This Week in Virology.

In his weekly clinical update, Dr. Griffin deep dives into recent domestic and global measles and mpox outbreaks, before reviewing recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2, discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how much oxygen is necessary for effective treatment of severe disease, how COVID-19 effects the cardiovascular system of children and adolescents with long COVID and how iron metabolism may be altered during long COVID.

Click arrow to play
Download TWiV 1098 (35 MB .mp3, 49 min)
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Links for this episode

Measles tracking (CDC)

Measles in Cook County (MMWR) 2:07

Gaps in measles vaccination drives viral surges (Infectious Disease Advisor) 11:06

Misinformation impacts public health? Seriously? (ID Society) 13:25

CDC alert for global and domestic measles cases and outbreaks (CDC) 13:43

Mpox in Kamituga associated with outbreak in DRB (Eurosurviellance) 14:41

Mpox in US, 2023 (MMWR)

Mpox in DRC, 2024 (reliefweb)

CDC guidance for respiratory diseases, COVID antiviral & emergence of clade I mpox (ID Society) 23:37

~5% of infected dead from mpox (CIDRAP)

First cases of mpox in Republic of Congo (AP News)

Respiratory disease surveillance (CDC)

RSV surveillance  (CDC) 15:11

RSV national trend (CDC)

Influenza/flu surveillance (CDC)

Influenza/flu map (CDC)

COVID-19  hospital admissions (CDC)

COVID-19 national trend (CDC) 18:24

COVID-19 wastewater testing (biobot)

Variant tracker (CDC)

Variant hospital admissions (CDC)

Multisystem inflammatory syndrome in children 2023 (MMWR) 19:00

Guidance for COVID-19 in children and adolescents (JPIDS) 21:18

CDC Quarantine guidelines (CDC)

NIH COVID-19 treatment guidelines (NIH) 23:23

Molnupiravir safety and efficacy (JMV)

CDC Quarantine guidelines (CDC)

NIH COVID-19 treatment guidelines (NIH)

What do when your heathcare provider is infected with SARS-CoV-2 (CDC)

Managing healthcare staffing shortages (CDC)

Steroids,dexamethasone at the right time (OFID)

Anticoagulation guidelines (hematology.org)

High/low oxygenation target (JAMA) 24:09

How much oxygen is needed (JAMA) 25:13

Orthostatic intolerance in long COVID and healthy volunteers (JMV) 26:31

Autonomic cardiac function in children and adolescents with long COVID (European Journal of Pediatrics) 34:13

Long COVID iron dysregulation and inflammatory stress erythropoiesis (Nat Imm) 35:11

Contribute to our ASTMH fundraiser at PWB 36:38

Letters read on TWiV 1098 37:15

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The post TWiV 1098: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.

Vincent travels to the fifth Giant Virus Meeting in Tegernsee, Germany and speaks with Sheree Yau and Victoria Queiroz about their research on picoeukaryotes (tiny algal cells) and their viruses, pithoviruses, and an educational kit for virology classes.

Host: Vincent Racaniello

Guests: Sheree Yau and Victoria Queiroz

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Download TWiV 1097 (41 MB .mp3, 57 min)
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MicrobeTV Discord Server

MicrobeTV store at Cafepress

Become a member of ASV (asv.org)

The New City by Dickson Despommier

Virophage control of antarctic algal host-virus dynamics (PNAS) 13:45

Virus-host coexistence in phytoplankton through the genomic lens (Sci Adv)

Two groups of pithoviruses (J Virol) 22:30

Educational toolkit for virology classes (J Virol) 45:27

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

The post TWiV 1097: Tiny cells and giant viruses in a castle first appeared on This Week in Virology.