In his weekly clinical update, Dr. Griffin discusses the recent increase in norovirus outbreaks, human cases of H5N1 avian influenza, before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, how effective Molnupiravir is and provides information for Columbia University Irving Medical Center’s long COVID treatment center.
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Links for this episode
- Norovirus: Waste water scan for 11 pathogens (WastewaterSCan)
- Adolescent with Influenza A H5N1 infection (NEJM)
- Highly pathogenic avian Influenza A ( H5N1) virus infections in humans (NEJM)
- Emerging threat of H5N1 to human health (NEJM)
- US respiratory virus activity (CDC Respiratory Illnesses)
- In-hospital outcomes of healthcare-associated Coronavirus Disease 2019 (Omicron) versus healthcare-associated Influenza (CID)
- Waste water scan for 11 pathogens (WastewaterSCan)
- US respiratory virus activity (CDC Respiratory Illnesses)
- Weekly surveillance report: cliff notes (CDC FluView)
- RSV: Waste water scan for 11 pathogens (WastewaterSCan)
- RSV-Network (CDC Respiratory Syncytial virus Infection)
- US respiratory virus activity (CDC Respiratory Illnesses)
- Waste water scan for 11 pathogens (WastewaterSCan)
- COVID-19 deaths (CDC)
- COVID-19 national and regional trends (CDC)
- COVID-19 variant tracker (CDC)
- SARS-CoV-2 genomes galore (Nextstrain)
- Where to get pemgarda (Pemgarda)
- EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
- Fusion center near you….if in NY (Prime Fusions)
- CDC Quarantine guidelines (CDC)
- NIH COVID-19 treatment guidelines (NIH)
- Infectious Disease Society guidelines for treatment and management (ID Society)
- Drug interaction checker (University of Liverpool)
- Molnupiravir safety and efficacy (JMV)
- Real clinical effectiveness of Molnupiravir against 30-day mortality (OFID)
- Convalescent plasma recommendation for immunocompromised (ID Society)
- What to do when sick with a respiratory virus (CDC)
- When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
- Managing healthcare staffing shortages (CDC)
- Steroids, dexamethasone at the right time (OFID)
- Anticoagulation guidelines (hematology.org)
- Daniel Griffin’s evidence based medical practices for long COVID (OFID)
- Long COVID hotline (Columbia : Columbia University Irving Medical Center)Post-COVID Condition Risk Factors and Symptom Clusters and Associations with Return to Pre-COVID Health (CID)
- Letters read on TWiV 1180
- Dr. Griffin’s COVID treatment summary (pdf)
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
The post TWiV 1180: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.
Guys don’t you think that it is little bit weird that a guy who lives 30 years with HIV and is still alive, and he is the example how HIV kills CD4 in vivo?
Most of the data in the paper were done with normal lymphoid tissue explants. The experiments with the elite controller were confirmatory but did not establish the concept. I don’t think it’s weird at all – most people with AIDS would be treated and hence not suitable for this study.
Why would you use an example that contradicts your data.The elite controllers are small percentage among people who have HIV .
They present this process of cell death as fast end efficient and then they show a guy who presumably dealt with that for 30 years? For me it means that you can have low number of CD4 and live normally without taking any drugs.
I do understand your concern. I’m going to bring this up on TWiV this Friday and see what the others think. It is strange to demonstrate pyroptosis in an individual who is free from disease!
He is not free from disease! He has very low CD4 T-cell count (156 cells / ul) and high viral load (85,756 copies/ml at the time of lymph node resection. He decided not to take ART since he was diagnosed.
Interesting. Many elite controllers have normal CD4 T cell counts. The viral load would make him *not* an elite controller.
One cannot hunt for viruses anywhere if we haven’t yet found a host for the viruses to infect in the first place.
If one found a virus somewhere it would be an evidence that more complex form of life must exist there.(or possibly it could be a contaminant from Earth)
Also, it would have to be a complete virus, otherwise just because you found a protein or other biomolecule it may not be possible to assign it to a virus or bacteria. Also, in the case that we did find something that resembles something here on earth we could not be sure of it’s function because it is under different conditions. For example if we found there something that looks like a capsid here on earth, on other planet it may be used as a receptor, since that planet’s conditions may allow it to behave that way.
Our view is restricted (no doubts), but we can presume that some principles of life on Earth can be similar to those on the planets with similar permissible conditions, so finding a partial viral genome sequence may give us possibility to say that life exists there and resembles life on earth. Of course, we should search only on the certain planets. I think it is quite hard or impossible to predict principles of life, others than on Earth, to seek for on the other planets, therefore hunting for viruses in space is much easier.