Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis.

Preprint servers, the structure of an antibody bound to Zika virus, blocking Zika virus replication in mosquitoes with Wolbachia, and killing carp in Australia with a herpesvirus are topics of this episode hosted by Vincent, Dickson, Alan, and Kathy.

Vincent, Alan, Rich and Marc discuss the finding that a limited number of incoming herpesviral genomes can replicate and express in a cell, and controlling viral replication in Aedes aegypti with a Wolbachia symbiont.

Vincent and Dick muse about the symbiotic bacterium, Wolbachia, that protects flies from viral infection, the origin of 2009 influenza H1N1 virus, and the lure of original antigenic sin.