TWiEVO 57: SARS-CoV-2 receptor binding evolution blooms

Jessie, Allie and Tyler join Nels and Vincent to describe their work on deep mutational scanning of the SARS-CoV-2 receptor binding domain.

Hosts: Nels Elde and Vincent Racaniello

Guests: Jesse Bloom, Allie Greaney, and Tyler Starr

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TWiEVO 56: Revising the drafts of coronavirus evolution

CoV_bank

Nels and Vincent continue their discussion of SARS-CoV-2 evolution, including understanding recurrent mutations in the viral genome, and the potential for re-emergence of the virus from an animal reservoir.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks 1:22:36

Nels – The Cell in Evolution
Vincent – Visual Science

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TWiEVO 55: Coronavirus evolution from soup to nuts

CoV_bank

Nels and Vincent continue their discussion of SARS-CoV-2 evolution, with a report that the coronavirus proofreading enzyme stimulates RNA recombination, and debunking the conclusion that a change in the viral spike glycoprotein is associated with increased human to human transmission.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks 1:07:44

Nels – In Memoriam: Gordon Lark
Vincent – John Oliver Discussion of Antibody Tests

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TWiEVO 54: Rough drafts of SARS-CoV-2 science

CoV_bank

Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, including function of the furin cleavage site, whether Vervet cells are an informative system, another bat isolate, and a nomenclature to assist genomic epidemiology.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks 1:13:59

Nels – EvoEco seminars
Vincent – Coronavirus book for children

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TWiEVO 53: Virus evolution by land and by sea and by CoV, part II

nextstrain.org

Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, focusing on what the genome sequences tell us about the virus.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks 1:24:55

Nels – Science Mill Explorer Zone
Vincent – COVID-19 treatment and therapy tracker

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TWiEVO 52: Virus evolution by land and by sea and by CoV

Nels and Vincent examine SARS-CoV-2 from an evolutionary viewpoint, examining what the spike glycoprotein sequence informs us about the origin of the virus.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks 1:18:59


Nels – Alejandro Sanchez TED Talk
Vincent – WHO SARS-CoV-2 Sitrep

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TWiEVO 51: The starting point paradox

helix-loop-helix

Nels and Vincent dive deep into evolution and consider how new proteins emerged billions of years ago, when there were no other proteins to serve as starting material.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks 1:01:10


Nels – Universal principled review
Vincent – Hostile Planet by National Geographic

Listener Pick

Courtney – Nightwish Endless Forms Most Beautiful and Shudder Before The Beautiful

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TWiEVO 50: I’m dreaming of a Y chromosome

Nels and Vincent discuss signatures of sex chromosome evolution revealed by assembly of a young vertebrate Y chromosome from 3-spined stickleback fish.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks


Nels – Genome from a 5,700-Year-Old Wad of Chewed Gum
Vincent – NJ Sea-Level Rise Reports

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TWiEVO 49: A giant podcast on giant viruses

Rich joins Nels and Vincent for a debriefing on the 4th Ringberg Symposium on Giant Virus Biology in Tegernsee, Germany.

Hosts: Nels Elde and Vincent Racaniello

Guest: Rich Condit

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Science Picks 1:42:56

Rich – Flightradar24
Nels – Deutsches Museum Munich
Vincent – Diversify Microbiology

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.

TWiEVO 48: Flipping out with choanos on caffeine

Nels and Vincent reveal a new choanoflagellate that forms multicellular cup shaped colonies that respond to light to alternate between feeding and swimming behavior.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks 1:24:00

Nels – How to write a great science paper by Cormac McCarthy
Vincent – Natural Selection Store

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