On the fifth anniversary of TWiEVO, Nels and Vincent invite 12 evolutionary biologists to describe exciting future directions for the field and their laboratory in the next five years.

Hosts: Nels Elde and Vincent Racaniello

Guests: Lillian Fritz Laylin, Talia Karasov, Andrew Kern, Sarah Tishkoff, Dmitri Petrov, Nancy Chen, Amanda Larracuente, John McCutcheon, Ambika Kamath, Chip Aquadro, Rebekah Rogers, Yaniv Braindvain, and Harmit Malik

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Science Picks 1:45:21

NelsScience Mill Virtual Tour and Benefit
VincentDas Coronavirus summaries

Music on TWiEVO is performed by Trampled by Turtles

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Nels and Vincent answer listener questions and discuss a newly discovered virus of amoeba with a nearly complete ORFan genome: none of the proteins encoded in the viral genome look like any other proteins.

Hosts: Nels Elde and Vincent Racaniello

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Links for this episode

Science Picks 1:22:45

Nels – Blog by Ambika Kamath
Vincent – TWiVerse

Music on TWiEVO is performed by Trampled by Turtles

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Simon and Heather join TWiEVO to discuss their analysis of the evolutionary history of ACE2 usage by coronaviruses in the Sarbecovirus genus.

Hosts: Nels Elde and Vincent Racaniello

Guests: Simon Anthony and Heather Wells

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Download TWiEVO 58  (54 MB .mp3, 90 min)
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Music on TWiEVO is performed by Trampled by Turtles

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Jessie, Allie and Tyler join Nels and Vincent to describe their work on deep mutational scanning of the SARS-CoV-2 receptor binding domain.

Hosts: Nels Elde and Vincent Racaniello

Guests: Jesse Bloom, Allie Greaney, and Tyler Starr

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Download TWiEVO 57  (50 MB .mp3, 84 min)
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Music on TWiEVO is performed by Trampled by Turtles

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CoV_bank

Nels and Vincent continue their discussion of SARS-CoV-2 evolution, including understanding recurrent mutations in the viral genome, and the potential for re-emergence of the virus from an animal reservoir.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks 1:22:36

Nels – The Cell in Evolution
VincentVisual Science

Music on TWiEVO is performed by Trampled by Turtles

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CoV_bank

Nels and Vincent continue their discussion of SARS-CoV-2 evolution, with a report that the coronavirus proofreading enzyme stimulates RNA recombination, and debunking the conclusion that a change in the viral spike glycoprotein is associated with increased human to human transmission.

Hosts: Nels Elde and Vincent Racaniello

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Download TWiEVO 55 (45 MB .mp3, 74 min)
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Science Picks 1:07:44

Nels – In Memoriam: Gordon Lark
VincentJohn Oliver Discussion of Antibody Tests

Music on TWiEVO is performed by Trampled by Turtles

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CoV_bank

Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, including function of the furin cleavage site, whether Vervet cells are an informative system, another bat isolate, and a nomenclature to assist genomic epidemiology.

Hosts: Nels Elde and Vincent Racaniello

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Download TWiEVO 54 (47 MB .mp3, 78 min)
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Science Picks 1:13:59

Nels – EvoEco seminars
VincentCoronavirus book for children

Music on TWiEVO is performed by Trampled by Turtles

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nextstrain.org

Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, focusing on what the genome sequences tell us about the virus.

Hosts: Nels Elde and Vincent Racaniello

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Download TWiEVO 53 (56 MB .mp3, 92 min)
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Science Picks 1:24:55

Nels – Science Mill Explorer Zone
VincentCOVID-19 treatment and therapy tracker

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Nels and Vincent examine SARS-CoV-2 from an evolutionary viewpoint, examining what the spike glycoprotein sequence informs us about the origin of the virus.

Hosts: Nels Elde and Vincent Racaniello

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Download TWiEVO 52 (50 MB .mp3, 93 min)
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Science Picks 1:18:59


Nels – Alejandro Sanchez TED Talk
VincentWHO SARS-CoV-2 Sitrep

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helix-loop-helix

Nels and Vincent dive deep into evolution and consider how new proteins emerged billions of years ago, when there were no other proteins to serve as starting material.

Hosts: Nels Elde and Vincent Racaniello

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Download TWiEVO 51 (43 MB .mp3, 71 min)
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Science Picks 1:01:10


Nels – Universal principled review
VincentHostile Planet by National Geographic

Listener Pick

Courtney – Nightwish Endless Forms Most Beautiful and Shudder Before The Beautiful

Music on TWiEVO is performed by Trampled by Turtles

Send your evolution questions and comments to twievo@microbe.tv