TWiEVO 60: Five years of TWiEVO on the future of our past

On the fifth anniversary of TWiEVO, Nels and Vincent invite 12 evolutionary biologists to describe exciting future directions for the field and their laboratory in the next five years.

Hosts: Nels Elde and Vincent Racaniello

Guests: Lillian Fritz Laylin, Talia Karasov, Andrew Kern, Sarah Tishkoff, Dmitri Petrov, Nancy Chen, Amanda Larracuente, John McCutcheon, Ambika Kamath, Chip Aquadro, Rebekah Rogers, Yaniv Braindvain, and Harmit Malik

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Science Picks 1:45:21

Nels – Science Mill Virtual Tour and Benefit
Vincent – Das Coronavirus summaries

Music on TWiEVO is performed by Trampled by Turtles

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TWiEVO 59: The hypothesis giving tree

Nels and Vincent answer listener questions and discuss a newly discovered virus of amoeba with a nearly complete ORFan genome: none of the proteins encoded in the viral genome look like any other proteins.

Hosts: Nels Elde and Vincent Racaniello

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Links for this episode

Science Picks 1:22:45

Nels – Blog by Ambika Kamath
Vincent – TWiVerse

Music on TWiEVO is performed by Trampled by Turtles

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TWiEVO 58: Not all coronaviruses ACE2 the test

Simon and Heather join TWiEVO to discuss their analysis of the evolutionary history of ACE2 usage by coronaviruses in the Sarbecovirus genus.

Hosts: Nels Elde and Vincent Racaniello

Guests: Simon Anthony and Heather Wells

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Music on TWiEVO is performed by Trampled by Turtles

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TWiEVO 57: SARS-CoV-2 receptor binding evolution blooms

Jessie, Allie and Tyler join Nels and Vincent to describe their work on deep mutational scanning of the SARS-CoV-2 receptor binding domain.

Hosts: Nels Elde and Vincent Racaniello

Guests: Jesse Bloom, Allie Greaney, and Tyler Starr

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Music on TWiEVO is performed by Trampled by Turtles

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TWiEVO 56: Revising the drafts of coronavirus evolution

CoV_bank

Nels and Vincent continue their discussion of SARS-CoV-2 evolution, including understanding recurrent mutations in the viral genome, and the potential for re-emergence of the virus from an animal reservoir.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks 1:22:36

Nels – The Cell in Evolution
Vincent – Visual Science

Music on TWiEVO is performed by Trampled by Turtles

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TWiEVO 55: Coronavirus evolution from soup to nuts

CoV_bank

Nels and Vincent continue their discussion of SARS-CoV-2 evolution, with a report that the coronavirus proofreading enzyme stimulates RNA recombination, and debunking the conclusion that a change in the viral spike glycoprotein is associated with increased human to human transmission.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks 1:07:44

Nels – In Memoriam: Gordon Lark
Vincent – John Oliver Discussion of Antibody Tests

Music on TWiEVO is performed by Trampled by Turtles

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TWiEVO 54: Rough drafts of SARS-CoV-2 science

CoV_bank

Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, including function of the furin cleavage site, whether Vervet cells are an informative system, another bat isolate, and a nomenclature to assist genomic epidemiology.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks 1:13:59

Nels – EvoEco seminars
Vincent – Coronavirus book for children

Music on TWiEVO is performed by Trampled by Turtles

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TWiEVO 53: Virus evolution by land and by sea and by CoV, part II

nextstrain.org

Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, focusing on what the genome sequences tell us about the virus.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks 1:24:55

Nels – Science Mill Explorer Zone
Vincent – COVID-19 treatment and therapy tracker

Music on TWiEVO is performed by Trampled by Turtles

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TWiEVO 52: Virus evolution by land and by sea and by CoV

Nels and Vincent examine SARS-CoV-2 from an evolutionary viewpoint, examining what the spike glycoprotein sequence informs us about the origin of the virus.

Hosts: Nels Elde and Vincent Racaniello

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Science Picks 1:18:59


Nels – Alejandro Sanchez TED Talk
Vincent – WHO SARS-CoV-2 Sitrep

Music on TWiEVO is performed by Trampled by Turtles

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TWiEVO 51: The starting point paradox

helix-loop-helix

Nels and Vincent dive deep into evolution and consider how new proteins emerged billions of years ago, when there were no other proteins to serve as starting material.

Hosts: Nels Elde and Vincent Racaniello

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Download TWiEVO 51 (43 MB .mp3, 71 min)
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Science Picks 1:01:10


Nels – Universal principled review
Vincent – Hostile Planet by National Geographic

Listener Pick

Courtney – Nightwish Endless Forms Most Beautiful and Shudder Before The Beautiful

Music on TWiEVO is performed by Trampled by Turtles

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