This Week in Evolution

TWiEVO 41: Where do baby genes come from?

March 20, 2019

Nels and Vincent explore the evolution of new protein-coding genes de novo from nocoding DNA sequences, using the antifreeze protein of northern codfish as a model.

Hosts: Nels Elde and Vincent Racaniello

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Evolution of antifreeze protein gene in codfish (PNAS)
Codfish diversity (Cheng lab)
Frankentomatoes (Huff Post)
Image credit
Time stamps by Jolene. Thanks!

Science Picks

Nels – Science at Sundance reviews

Vincent – The Rise and Fall of Scientific Authority

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Send your evolution questions and comments to twievo@microbe.tv

TWiEVO 40: Eau de bee

February 15, 2019

Nels and Vincent move back to reproductive isolation – this time, pre-zygotic, in the charismatic orchid bee where the males make chemically distinct perfumes to attract mates of the same species.

Hosts: Nels Elde and Vincent Racaniello

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Olfactory receptor gene underlies reproductive isolation (biorXiv) 4:49
Image credit
Time stamps by Jolene. Thanks!

Science Picks 59:59

Nels – Nature Zen: Orchid Bees Are Shiny
Vincent – What You Believe About Science Denial May Be All Wrong

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Send your evolution questions and comments to twievo@microbe.tv

TWiEVO 39: In a Legionella of their own

January 26, 2019

Nels and Vincent look at the intracellular bacteria Legionella from an evolutionary perspective: the role of gene acquisition and reshuffling from plants, animals, fungi, and archaea in the emergence of human pathogens.

Hosts: Nels Elde and Vincent Racaniello

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Over 18,000 effectors in Legionella genome (PNAS) 4:08
Carmen Buchrieser lab 4:31
Howard Shuman 10:04
Image credit

Science Picks 1:06:46

Nels – Science in Film (twitter)
Vincent – Lunar Eclipse 101

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TWiEVO 38: Evolving to evolve

December 24, 2018

Nels and Vincent reveal a highly conserved protein that acts as an evolvability factor, increasing mutation and the ability of bacteria to become resistant to antibiotics.

Hosts: Nels Elde and Vincent Racaniello

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Inhibiting evolution of antibiotic resistance (Mol Cell) 1:47
Pushing viruses over the error threshold (virology blog) 48:22
Image credit
Letters read on TWiEVO 38 57:58

Science Picks 1:11:48

Nels – Science/nature illustrator/artist Rachel Ignotofsky (website, Etsy shop)
Vincent – Life Ascending by Nick Lane

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TWiEVO 37: A tangled tree on the Quammens

November 17, 2018

David Quammen joins Nels and Vincent to talk about his new book, A Tangled Tree, including evolutionary trees, Carl Woese, Lynn Margulis, horizontal gene transfer, and much more.

Hosts: Nels Elde and Vincent Racaniello

Guest: David Quammen

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David’s website 00:52
David on TWiV 408, Boston Quammens 2:08
Axel Erlandson’s trees reimagined – Gilroy Gardens 1:22:39

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TWiEVO 36: All’s not quiet on the telomeric front

October 24, 2018

Mia joins Nels and Vincent to unravel their finding that the transposons that maintain the ends of chromosomes in Drosophila have evolved in conflict with the genome.

Hosts: Nels Elde and Vincent Racaniello

Guest: Mia Levine

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Levine Lab at U Penn 1:34
Telomere elongation without telomerase (bioRxiv) 9:57
Letters read on TWiEVO 36 57:05

Science Picks 1:06:43

Nels – Cinema Science podcast
Vincent – Mastodon bones unearthed (Instagram, Grand Rapids News)

Music on TWiEVO is performed by Trampled by Turtles

Send your evolution questions and comments to twievo@microbe.tv

TWiEVO 35: Strawberry sex chromosomes forever

September 21, 2018

Nels and Vincent reveal that female-specific DNA associated with sex in strawberries has repeatedly changed its genomic location, possibly linking new genes with sex.

Hosts: Nels Elde and Vincent Racaniello

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Jumping sex genes in strawberries (PLoS Biol) 5:17, 36:29
Red Queen by Matt Ridley 17:11
Image credit
Letters read on TWiEVO 35 1:02:03

Science Picks 1:19:52

Nels – New snailfish and Cloned crayfish
Vincent – A PhD Lab Coat Ceremony

Listener Picks

Steve – Diversity in simple blobs
Justin – On Growth and Form by D’Arcy Wentworth Thompson (free)

Music on TWiEVO is performed by Trampled by Turtles

Send your evolution questions and comments to twievo@microbe.tv

TWiEVO 34: You don’t know what you’ve got ‘til it’s PON

August 16, 2018

Nels and Vincent discuss how the loss of an enzyme in marine mammals millions of years ago now makes them at risk for neurotoxicity caused by human-made organophosphorous pesticides.

Hosts: Nels Elde and Vincent Racaniello

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Ancient losses of paraoxonase I (Science) 5:52, 15:49
Big Yellow Taxi (YouTube) 1:00:04
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Letters read on TWiEVO 34 1:03:47

Hey farmer farmer put away the chlor-pyri-fus
I don’t care about spots on my apples
Leave me the manatee and walruses

Science Picks 1:13:56

Nels – New dinosaur discovered in Utah
Vincent – The Song of the Dodo by David Quammen

Music on TWiEVO is performed by Trampled by Turtles

Send your evolution questions and comments to twievo@microbe.tv

TWiEVO 33: Fly by virus

July 24, 2018

Nels and Vincent at ASV 2018

Nels and Vincent are astounded by the finding of an insect-derived virus in a fungus that manipulates the behavior of flies.

Hosts: Nels Elde and Vincent Racaniello

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Virus in fungus in fly (bioRxiv) 9:13, 28:40
On a leaf, no one can hear you scream (TWiV 443) 26:18
Nels gives Benzer Lecture (YouTube) 27:27
Domestication of fungal fly pathogen (bioRxiv) 28:52
Sequencing E. muscae genome (10X genomics) 34:02, 37:20
Eisen’s twitter stream on new iflavirus (Twitter) 38:09

Science Picks 1:09:26

Nels – Mindsuckers; getting photos; Anand Varma photos
Vincent – Happy Birthday Gregor Mendel

Music on TWiEVO is performed by Trampled by Turtles

Send your evolution questions and comments to twievo@microbe.tv

TWiEVO 32: Never not neutral

June 19, 2018

Matt joins Nels and Vincent to discuss the neutral theory of evolution and its rejection in light of genome-scale data.

Hosts: Nels Elde and Vincent Racaniello

Guest: Matt Hahn

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Hahn Lab 1:24, 4:04
Molecular Population Genetics by Matt Hahn 14:02
Neutral theory in light of natural selection (Mol Biol Evol) 17:54
Neutral Sequence Fallacy (Assembly of Fragments) 24:45
Splendor and misery of adaptation (BMC Biol) 34:55
Image credit 38:23
Letters read on TWiEVO 32 1:02:40

Science Picks 1:10:35

Nels – Inaugural Transposon Day
Vincent – How many human genes?

Listener Pick

Anne – Plants repeatedly lose ability to obtain nitrogen

Music on TWiEVO is performed by Trampled by Turtles

Send your evolution questions and comments to twievo@microbe.tv

TWiEVO 41: Where do baby genes come from?

Science Picks

TWiEVO 40: Eau de bee

Science Picks 59:59

TWiEVO 39: In a Legionella of their own

Science Picks 1:06:46

TWiEVO 38: Evolving to evolve

Science Picks 1:11:48

TWiEVO 37: A tangled tree on the Quammens

TWiEVO 36: All’s not quiet on the telomeric front

Science Picks 1:06:43

TWiEVO 35: Strawberry sex chromosomes forever

Science Picks 1:19:52

Listener Picks

TWiEVO 34: You don’t know what you’ve got ‘til it’s PON

Science Picks 1:13:56

TWiEVO 33: Fly by virus

Science Picks 1:09:26

TWiEVO 32: Never not neutral

Science Picks 1:10:35

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