Matters Microbial #103: Giant Bacteria and Bigger Questions

August 14, 2025

Today, Dr. Jean-Marie Volland, Assistant Professor at the University of California in Santa Barbara joins the #QualityQuorum to discuss the discovery and analysis of the (so far) largest bacterium known:  Thiomargarita magnifica, which can be a centimeter long! Definitely #OMG and #WTM!

Host: Mark O. Martin

Guest: Jean-Marie Volland

Download MM103 (39 MB MP3, 64 mins)

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  • Here is a review article discussing the environmental persistence of antibiotic resistance genes.
  • Here is a link to Episode 41 of this podcast, with Dr. Esther Angert, on the wily ways of Epulopiscium.
  • A review article regarding “giant bacteria.”
  • A video explaining the surface area versus volume issue discussed on this podcast.
  • An interesting article exploring how much “territory” is within a bacterial cell; this is relevant to bacterial polyploidy.
  • A review of Epulopiscium, the first of the giant bacteria described.
  • Here is a video of Epulopisicum.  
  • An article describing polyploidy in Epulopiscium
  • A review of Thiomargarita nambiensis, another giant bacterium with an interesting strategy.
  • Here is a video of T. nambiensis
  • An essay from “Small Things Considered” about the very, very strange world of Achromatium, which is so worth your time.
  • The first report of Thiomargarita magnifica, the world’s largest bacterium (thus far) by Dr. Volland and coauthors.
  • Here is a report on this discovery for novice micronauts.
  • A great review about giant microbes by Dr. Volland.
  • A more recent article on T. magnifica by Dr. Volland and colleagues.
  • A video regarding T. magnifica.
  • A video by Dr. Volland describing T. magnifica work.
  • A lovely essay regarding how Dr. Volland and family trekked California searching for giant microbes. Don’t miss!
  • The research lab website for Dr. Volland and colleagues, with so much interesting information.
  • The faculty website for Dr. Volland at UC Santa Barbara.

Intro music is by Reber Clark

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