In his weekly clinical update, Dr. Griffin informs us about mpox circulation and new vaccine approval, the Marburg virus outbreak in Rwanda, and the largest outbreak of whooping cough in a decade before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunity among those over 65th following the 3rd dose of the COVID-19 mRNA vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, how well the SARS-CoV-2 rapid antigen test performed, what do when healthcare workers succumb to SARS-CoV-2 infection, the effect of remdesivir on survival and readmission of hospitalized patients, if cognitive impairment following virus infection impairs one’s driving and how long COVID affects Chinese society.
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Links for this episode
Undiagnosed MPXV infections are high in men who have sex with men (BMC Infectious Diseases)
WHO, now a vaccine approval agency, Jynneos for teens (CIDRAP)
Mpox outbreak global trends (WHO)
How to stop Marburg virus (Rwanda Biomedical Centre)
Marburg virus fact sheet (Rwanda Biomedical Centre)
Largest whooping cough outbreak in US in a decade (NPR)
COVID-19 deaths (CDC)
COVID-19 national and regional trends (CDC)
Waste water scan for 11 pathogens (WastewaterSCan)
COVID-19 variant tracker (CDC)
SARS-CoV-2 genomes galore (Nextstrain)
Insurance relates to effectiveness and waning of immunity following 3rd dose of mRNA COVID-19 vaccine? (JID)
New preventive COVID-19 agent (ISDA)
IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)
Where to get pemgarda (Pemgarda)
EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
How well do you test: performance of the SARS-CoV-2 antigen rapid detection test (eBioMedicine)
CDC Quarantine guidelines (CDC)
NIH COVID-19 treatment guidelines (NIH)
Infectious Disease Society guidelines for treatment and management (ID Society)
Drug interaction checker (University of Liverpool)
Molnupiravir safety and efficacy (JMV)
Convalescent plasma recommendation for immunocompromised (ID Society)
What to do when sick with a respiratory virus (CDC)
When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
Managing healthcare staffing shortages (CDC)
Steroids, dexamethasone at the right time (OFID)
Anticoagulation guidelines (hematology.org)
Remdesivir-associated survival outcomes among immunocompromised patients (CID)
Remdesivir Effectiveness in Reducing the Risk of 30-day Readmission in Vulnerable Patients (CID)
Measurement of circulating viral antigens post-SARS-CoV-2 infection (CMI: Clinical Microbiology and Infection)
DUCI: driving under cognitive influence of COVID-19 (Neurology)
Long COVID facts and findings: (LANCET: Regional Health Western Pacific)
Letters read on TWiV 1158
Dr. Griffin’s COVID treatment summary (pdf)
Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
The post TWiV 1158: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.
Hi,
I just discovered your podcasts, ideal for endless TCID50.
Thank you and your firends for your excellent analyses, it is a great pleasure to listen to you.
Remi, french Virologist from Belfast.
On the topic of virus textbooks, there aren’t any basic ones. While not a textbook, Carl Zimmer’s “A Planet of Viruses” give some very cool stories and insight into viral evolution, pathogenesis and infection.
Great TWIV as usual. A quick note on the protein transduction from the PLoS ONE paper: there is an old literature on this stuff, going back to a 1999 Science paper (Schwarze, Ho, Vocero-Akbani and Dowdy, 285: 1569-1572). Steven Dowdy’s group said that beta-gal protein fused to TAT went into “all tissues in mice, including the brain” after an IP injection of protein. Now, I don’t know how well this has held up over time – it’s not my field – but there continues to be fairly widespread use of this technique suggesting it actually works. A quick Goggle search shows that Dowdy is HHMI and continues to publish on this ad nauseum, as one might expect based on this discovery. So while it sounds seriously crazy, the largest perceived hurdle of this paper might have already been cleared. Keep up the great work: it helps me survive my commute and feeds my lost passion for virology.
Abbie Smith was great on this TWIV. Her enthusiasm and ability to articulate complex ideas really added a lot to the show plus, you know, she was fun. I think Vince should try to add her as a semi-regular host. Maybe when Dr. Despommier is gone.
Totally agree.
I would suggest Principles of Molecular Virology by Alan Cann which has a fifth edition coming out this month. I am a PhD student so maybe I am wrong, but I thought it had a great “for dummies” approach. Moreover, the CD has exercises and flash videos about the important topics. I read half of the forth edition from the library, but stopped when I found out about the fifth edition.