TWiV reveals a novel H5N1 reassortant virus in Cambodia, circulating vaccine derived poliovirus type 2 in more countries, circulation in the blood of humans of infectious parvovirus B19 coated with active proteases, and B cell receptor dependent enhancement of dengue virus infection.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
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- Novel H5N1 in Cambodia (medRxiv) 6:28
- More cVDVP2 circulation (polioeradication.org) 11:48
- Infectious parvovirus B19 with proteases (Nat Comm) 12:16
- B cell receptor enhancement of dengue disease (PLoS Path) 42:31
- Letters read on TWiV 1167 1:00:53
- Timestamps by Jolene. Thanks!
Weekly Picks 1:28:20
Brianne – See How Many Lives Vaccines Have Saved Around the World based on Lancet study
Dickson – 2024 Wildlife Photographer of the Year
Kathy – 450 Million year old arthropods preserved in fool’s gold. Primary article Pyrite video
Vincent – ‘We need to be ready for a new world’: scientists globally react to Trump election win
Listener Picks
Jack – Coronavirus vaccine update
Intro music is by Ronald Jenkees
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The post TWiV 1167: Virus cloak and entry first appeared on This Week in Virology.
In regards to the swine influenza story…a whole slew of reassortments between the pandemic human H1N1, which jumped back into swine and various classical swine origin strains are now occurring. Anywhere from 0 to 5 pH1N1 segments are found in the last 2 years within the swine H3N2 strains, don’t quote me, but I believe the one in the press lately says “only” the M segment of pH1N1….but at its heart ALL are derived from the TRIG-cassette. I’ve been doing alignments on the pH1N1 human and the swine H3N2 isolates of the last 2 years and I can tell you that besides HA and NA the other 6 genome segments (NS1, PB1, PB2, etc) are still highly similar between human and swine. What I find very interesting is high-path H5N1 is just fine in pigs…in fact pigs seem to tolerate many influenza strains with only minor symptoms. What host factors do swine have or do not have compared to humans that allow this? So little known about influenza in swine.
With respect to HFRS, if you are an Honorary Fellow of the Royal Society – you’re in trouble!
Dorian