For the final episode of 2021, TWiV reviews an experimental infectious attenuated Lassa fever vaccine based on a codon-deoptimized glycoprotein gene, and SARS-CoV-2 infection of free-ranging white-tailed deer.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Download TWiV 847 (61 MB .mp3, 102 min)
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Links for this episode
- Codon-deoptimized Lassa fever vaccine (mBio) 3:52
- Attenuation of dengue virus by codon deoptimization (TWiV 351) 11:52
- Codon deoptimization of poliovirus and RS virus (TWiV 740) 11:54
- Codon deoptimization of DNA viruses (TWiV 362 letters) 11:58
- CEPI on TWiV 612 31:37
- SARS-CoV-2 in white-tailed deer (Nature) 39:59
- Letters read on TWiV 847 1:02:00
- Timestamps by Jolene. Thanks!
Weekly Picks 1:27:39
Dickson – EO Wilson (Ants and The Conversation)
Brianne – The Best Fun Science Stories of 2021
Kathy – Using sound for data analysis; chemotactic bacteria and Moo loo story
Alan – Owls of the Easern Ice, by Jonathan Slaght
Vincent – TWiV 9: Fever! The discovery of Lassa virus and TWiV 548: Mice, shrews, and caterpillars
Listener Picks
Larry – Immunity
Jeff – Daily Hospital Surveillance Report
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Greetings, Molecular Wizards 😉
Thank you for the invigorating enthusiasm for explicating such relevant, complicated, and essential modern science for non-scientists and scientists alike! I wish more of our scientific community would bring their excitement for the biological world to the public attention.
But that is not why I am commenting. I have to tell Vincent (may I call you Vincent?) that, based on your recent recommendation, I acquired a copy of John Fuller’s book “Fever! – The Hunt for a New killer Virus”. I thought you would be interested to hear that the 1974 Reader’s Digest hardcover edition has a printed a facsimile of the “Yellow Card” as the front and back endpiece. There is an Atlanta address, a (404) phone number, plus a nights-and-weekend number for the physician to alert the CDC if their patient is suspect for smallpox, yellow fever, plague or cholera. Hits home in the context of the Lassa fever story, and it is an interesting historical footnote relevant to the international public health challenges of today. Would be delighted if Dr. Despommier would share his thoughts on this particular era in the story of global communicable disease.
Also, Happy New Year!!
I have been listening to this podcast every night since the beginning of the pandemic. It was only today that I discovered this wasn’t just a podcast, but a video! I cannot describe how wonderful it was to see all your faces for the first time after “getting to know you” for so long. On seeing you, I felt like I was beaming with such delight and affection for you all. Thank you for your fascinating and insightful discourse. Your intelligent musings probably mean a lot more to people than you might imagine.