SciArtist Laura Splan joins TWiV to reveal her transdisciplinary work that intersects science, technology, design and culture, then we discuss an inverse correlation between mumps virus antibodies induced by MMR vaccine and COVID-19 severity, and whether ivermectin is indicated for treatment of COVID-19.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Laura Splan
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Download TWiV 691 (79 MB .mp3, 132 min)
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Links for this episode
- Laura Splan website 57:56, 1:05:08
- BSL-3 Assistant Manager position 1:07:35
- MMR titers in recovered COVID-19 patients (mBio) 1:12:06
- Ivermectin and SARS-CoV-2 (TWiV 599) 1:30:55
- Treatment of COVID-19 with ivermectin (Int J Inf Dis) 1:32:08
- Ivermectin approved dosing (Mayo Clinic) 1:34:00
- Briefing document for Pfizer vaccine (FDA) 1:38:29
- Vaccinated? Wear a mask (NY Times) 1:44:19
- Efficacy of ChAdOx1 vaccine (Lancet) 1:47:43
- Mix & Match Pfizer & Oxford jabs (Times Long) 1:48:08
- SARS-CoV-2 seroprevalence in Seattle (medRxiv) 1:50:04
- Timestamps by Jolene. Thanks!
Weekly Picks 1:51:36
Brianne – Patterns for Virus snowflakes
Kathy – 2020 Nobel Prize lectures (hepatitis C) (link to all and concert) Historical review by Harvey Alter
Rich – New Data Confirm 2020 SO is Upper Centaur Rocket Booster from 1960’s (Wiki)
Vincent – The Right Stuff
Listener Pick
Miikael – Tiny tweak behind COVID-19 vaccines
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Pandemic Poem 2- an Exchange.
If I had time
This moment
Would, fractal-like,
Spiralling, grow and expand,
Persist and remain
Forever
Or
At least until
I had explored
And understood
And communicated,
And been…
But
I have to cook-
And 5 people of varying capacities must eat,
Trusting that we have enough in common,
That my taste is good enough
(One man’s food is another’s poison, after all)
That their needs are met
And they survive.
Which of our metaphors
Are good enough?
Like Bowlby’s ‘good enough mother’:
Freedom is:
Freedom from pain,
From hunger, from want.
Freedom to roam,
Freedom to behave…
Freedom to breathe.
A series of priorities.
Which of our metaphors, if any, is good enough?
And what, of our urges,
Is not born of
Our constantly evolving biochemical negotiations.
Which of our metaphors then,
Is not a failure
To truly represent them?
Lost in translation…
The antagonism is unavoidable
When what it all boils down to is:
Fit/No Fit.
Uninterrupted, at an interface with itself,
Ravelling and unravelling, entering and leaving, trying and failing,
Feeling, seeing and hearing,
Hypotheses evolving.
Life is Art.
And Art is Life, focussed.
Also , for repeated ‘A’s: Chopin’s Prelude no. 15, op. 28 (raindrop prelude); maybe not 33 per phrase but I haven’t counted!
here’s Horowitz
https://www.youtube.com/watch?v=Sh03YXzvDF4
Reading 12/10/20Twitter post of Zeynep Tufekci (glad I don’t have to pronounce that!). She shows a graph that Brianne alluded to on TWiV 691 about the efficacy of a single shot (like Moderna or Pfizer’s MRNA vaccines). Says that there is evidence that a single shot is maybe 80% effective – which you can kinda-sorta tell by the number of infectees between the 1st and 2nd shots. in the phase 3 trials.
There’s a graph that shows the placebo arm of the study continuing to get Covid-19 while the single shot folks are 80% reduced infection. Given that there is a super shortage of either vaccine for Americans, mightn’t it be best to gain coverage by going with a single shot. What do you think?
Personally, I thot there might be a lot of other things you’d like to know like how LONG immunity would last and how/when you’d ever get your second shot. What would that do to long term immunity?
Here’s a link and one of the 1st responses was from Michael Mina who agrees with her.
https://twitter.com/zeynep/status/1337125198437502978
posting the embeded tweet below which maybe will work.
As of this date, 12/10/2020, the download link on this webpage https://www.microbe.tv/twiv/twiv-691/ is an ort from the TWiV 688 webpage. The link points to the TWiV688 download and its text is also TWiV688 instead of TWiV691.
Thanks for that C&EN link, Mikael! I had been hunting for the exact basis for the Pro substitutions and had assumed that it was merely to stabilize and give the antigen a longer half-life. The actual reason is much better!