Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and David Baltimore
Vincent, Alan, and Rich celebrate the 100th episode of TWiV by talking about viruses with Nobel Laureate David Baltimore.
Click the arrow above to play, or right-click to download TWiV #100 (68 MB .mp3, 94 minutes)
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Links for this episode:
- David’s early papers on poliovirus and mengovirus RNA synthesis
- Reverse transcriptase found by Baltimore and Temin (pdfs)
- Nobel Prize in Physiology or Medicine 1975
- David fishing (Picasa web album)
- The David Baltimore asteroid belt
- Cedric’s essay The ‘Death’ of a Virus (pdf)
- Letters read on TWiV 100
Weekly Science Picks
Alan – TimeTree
Rich – The neurons that shaped civilization
Vincent – Ahead of the Curve: David Baltimore’s Life in Science by Shane Crotty
Send your virology questions and comments to firstname.lastname@example.org.
I liked Dr. Baltimore’s advice. I frequently ask myself, “Ok, am I sure that this is the path I want to take? It’s not too late to turn back and become an architect.” but, of course, the answer is always yes. I do want to go into science because I can’t imagine myself doing anything else in life.
Having listened to and watched many of your shows about the Baltimore cycle I am still confused!
Is the RNA in the virus genome the same as the mRNA that is required by the host cell ribosome?
Once the virus is unpacked can the +RNA go directly to the ribosome and be transcribed?
It seems to me that at some points you say something that makes me think Yes and then later the opposite.
p.s I haven’t listened to TWIV100 yet.
Maybe my question is answered there!
Awesome. I remember sitting in a virology lecture as a student and our Prof announced the discovery of mRNA splicing!!
These memories are worth recalling. I was a PhD student when my
advisor, Peter Palese, came back from a meeting and said ‘The next big
thing is splicing’.
12-22-2020 Great to find this podcast, referenced in the Virology 2020 lecture #9 (reverse transcription and integration). From the viewpoint of 2020, the discussion holds up well. It’ll be fun to see the Virology 2021 lectures.
LOL, finding you hanging out here. 😀