TWiV 169: Epidemiology causes conclusions (p less than 0.01)

Snow cholera mapHosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Michael Walsh

Michael and the TWiV team review epidemiology basics, including fatality ratios.

Click the arrow above to play, or right-click to download TWiV 169 (64 MB .mp3, 152 minutes).

Right-click this link to download only our discussion on how to read a science paper (22 MB .mp3, 30 minutes).

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Links for this episode:

Weekly Science Picks

Michael – Love my epi
Dickson – Bacteria array detects arsenic
Rich – Dunning-Kruger effect
Alan – Environmental Economics
Vincent – Don’t censor influenza research

Listener Pick of the Week

Simon – The Great Mortality by John Kelly

Send your virology questions and comments to twiv@microbe.tv.

TWiV 168: Super CalTech prophylaxis and ferret runny noses

adeno-associated virusHosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Welkin Johnson

Welkin joins the TWiV team for a discussion of HIV prophylaxis using vectored antibodies, and the influenza H5N1 virus studies in ferrets that were not redacted.

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Links for this episode:

Weekly Science Picks

Welkin – Virtual PI (Nature)
Dickson – Drain the Ocean
Rich – Nova: To the Moon
Alan – Robert Falcon Scott on Twitter and the Terra Nova expedition
Vincent – Hello, Mr. Chips (I, Cringely)

Listener Pick of the Week

Charlotte – And the Band Played On

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TWiV 167: It starts with a cough

Lipkin in ContagionHosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Alan Dove

The complete TWiVome deconstructs the movie Contagion.

Click the arrow above to play, or right-click to download TWiV 167 (53 MB .mp3, 88  minutes).

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Links for this episode:

Weekly Science Picks

Dickson – Guinea Pig Doctors by Jon Franklin
Rich – Learn to appreciate technology and Everythings amazing and nobodys happy (YouTube)
Alan – JD Hooker slide collection
Vincent – iTunes U app and iBooks Author

Listener Pick of the Week

Judi – Makers of Many Things by Eva March Tappan

Send your virology questions and comments to twiv@microbe.tv.

TWiV 166: Breaking and entering

npc1 ebolaHosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Alan Dove

Vincent, Dickson, Rich, and Alan review cell proteins essential for entry of hepatitis C, Ebola, and measles viruses.

Click the arrow above to play, or right-click to download TWiV 166 (59 MB .mp3,  98 minutes).

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Links for this episode:

Weekly Science Picks

Dickson – What are you swimming with?
Rich – Twelve monkeys
Alan – Kindle Touch
Vincent – Microbe news (thanks to Dave Winer)

Listener Pick of the Week

Eric – The Nature of Things with David Suzuki
Lance – Trials and Errors (Wired)

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TWiV 165: The email zone

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Alan Dove

Vincent, Dickson, Rich, and Alan answer listener questions about XMRV, cytomegalovirus, latency, shingles vaccine, myxomavirus and rabbits, and more.

Click the arrow above to play, or right-click to download TWiV 165 (61 MB .mp3, 102 minutes).

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Links for this episode:

Weekly Science Picks

Dickson – Creation
Rich – America’s Science Decline
Alan – Out of context science
Vincent – The Scientist Top 10 Innovations 2011

Listener Pick of the Week

Jim – Christoph Adami: Finding life we can’t imagine (TED)
Tim – Patient Zero (Radiolab)
Mary – Natural Obsessions by Natalie Angier
Jimmy – Science Exchange

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TWiV 164: Six steps forward, four steps back

xmrvHosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Alan, and Rich review ten compelling virology stories of 2011.

Click the arrow above to play, or right-click to download TWiV 164 (60 MB .mp3, 99 minutes).

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Ten virology stories of 2011:

  1. XMRV, CFS, and prostate cancer (TWiV 119, 123, 136, 150)
  2. Influenza H5N1, ferrets, and the NSABB (TWiV 159)
  3. The Panic Virus (TWiV 117)
  4. Polio eradication (TWiV 127, 149)
  5. Viral oncotherapy (TWiV 124, 131, 142, 156)
  6. Hepatitis C virus (TWiV 130, 137, 141)
  7. Zinc finger nuclease and HIV therapy (TWiV 144)
  8. Bacteria help viruses (TWiV 154)
  9. Human papillomaviruses (TWiV 126)
  10. Combating dengue with Wolbachia (TWiV 115, 147)

Links for this episode:

Weekly Science Picks

Rich – Fundamentals of Molecular Virology by Nicholas H. Acheson
Alan – Fetch, with Ruff Ruffman
Vincent – Year end reviews at Rule of 6ix and Contagions

Listener Pick of the Week

Garren – Trillion-frame-per-second video
Judi – iBioMagazine
Ricardo – Brain Picking’s 11 best science books of 2011

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TWiV 163: What Rous wrought

fungal christmas treeHosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Alan Dove

Vincent, Dickson, Rich, and Alan review the 100 year old finding by Peyton Rous of a transmissible sarcoma of chickens, a discovery that ushered in the era of tumor virology.

Click the arrow above to play, or right-click to download TWiV 163 (61 MB .mp3, 102 minutes).

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Links for this episode:

Weekly Science Picks

Rich – The Log from the Sea of Cortez by John Steinbeck
Alan – Comet rise
Vincent – TWiV iPhone case

Listener Pick of the Week

Ronnie – How fungi celebrate Christmas
Kevin – EcoCyc app
Gabriel – ImmGen app

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TWiV 162: Transcription

Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Rich, and Alan continue Virology 101 with a discussion of transcription, the process of making mRNA from a DNA template.



Click the arrow above to play, or right-click to download TWiV 162 (56 MB .mp3, 93 minutes).

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Links for this episode:

Weekly Science Picks

Rich – 3D vaccinia virion
Alan – Happy Holidays from NOAA (YouTube)
Vincent – 17 year old wins $100,000 science prize

Listener Pick of the Week

Sarah – Critical Thinking (pdf),  diagnosing respiratory infections by gene signature (Cell Host Micro), and One Health Initiative (CDC page)

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transcription

TWiV 161: Concerto in B

antibodyHosts: Vincent Racaniello, Rich Condit, Alan Dove, and Gabriel Victora

Vincent, Rich, Alan and Gabriel review the production of antibodies by B cells, and how high affinity antibodies are selected in the germinal centers of lymph nodes.

Click the arrow above to play, or right-click to download TWiV 161 (71 MB .mp3, 118 minutes).

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Links for this episode:

Weekly Science Picks

Gabriel – Antibody-based protection against HIV (Nature)
Rich – Contact
Alan – Flu shot dystonia (YouTube)
Vincent – Sciflies and RocketHub

Listener Pick of the Week

Neva – Virus and retrovirus
Ayesha – The Life Scientific (BBC)

Send your virology questions and comments to twiv@microbe.tv.

TWiV 160: Moore tumor viruses

merkel carcinomaHosts: Vincent Racaniello, Rich Condit, Alan Dove, Dickson Despommier, and Patrick Moore

The TWiV team speaks with Patrick Moore about his discovery, with Yuan Chang, of two human tumor viruses, Kaposi’s sarcoma herpesvirus and Merkel cell polyomavirus.

Click the arrow above to play, or right-click to download TWiV 160 (66 MB .mp3, 109 minutes).

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Links for this episode:

Weekly Science Picks

Patrick – The Theory That Would Not Die by Sharon Bertsch McGrayne
Dickson – Foodborne illness acquired in the US (Emerging Inf Dis)
Rich – GATTACA
Alan – Cutting for Stone by Abraham Verghese
Vincent – Boxwave capacitative stylus

Listener Pick of the Week

Neva – 10+1 top science apps
Ricardo – Where’s the outrage?

Send your virology questions and comments to twiv@microbe.tv.

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Dickson D.
Despommier, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Jolene Ramsey, Ph.D.


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