This Week in Virology

TWiV 566: Chicken gumbo and a corona

September 22, 2019

The TWiV team reveals the protein corona that surrounds virus particles and influences infectivity and amyloid aggregation, and a proofreading-impaired herpesvirus that produces quasispecies-like populations.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guest: Kiki Warren

Click arrow to play
Download TWiV 566 (67 MB .mp3, 111 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Human fetal tissue research restrictions (The Scientist) 10:25
Viral protein corona (Nat Commun) 14:49
Proofreading-impaired herpesvirus (Nat Micro) 37:26
Phage quasispecies (Cell) 38:23
Letters read on TWiV 566 9:34, 1:16:30
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:29:39

Alan – Astronomy photographer of the year
Rich – Urban living leads to high cholesterol… in crows
Kiki – Reversal of epigenetic aging
Vincent – General Virology by SE Luria

Listener Picks

Sindhu – Sweden Solar System
Anthony – Surprising role of viruses in evolution with Eugene Koonin
Paul – The Obscure Virus Club

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 565: Karolinska virology

September 15, 2019

From the Karolinska Institute in Stockholm, Vincent speaks with Niklas Björkström, Ali Mirazimi, and Matti Sällberg about their work on the impact of chronic hepatitis C virus infection on NK cells, Crimean-Congo hemorrhagic fever virus vaccines, and immunotherapy to block entry of hepatitis B and D viruses.

Hosts: Vincent Racaniello

Guests: Niklas Björkström, Ali Mirazimi, and Matti Sällberg

Click arrow to play
Download TWiV 565 (52 MB .mp3, 86 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Karolinska Huddinge 00:35, 10:31
CCHV experimental vaccines (J Virol) 15:17, 29:49
Increased NK function after antiviral cessation (J Inf Dis) 51:38
Impact of HCV infection on NK cell repertoire (Nat Comm) 35:27
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 564: Virology Nobel Prizes with Erling Norrby

September 8, 2019

From the 16th Smögen Summer Symposium on Virology, Vincent speaks with Erling Norrby about how he has used archival material to provide insight into early Nobel Prizes for research on viruses.

Hosts: Vincent Racaniello

Guest: Erling Norrby

Click arrow to play
Download TWiV 564 (45 MB .mp3, 74 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Swedish Society for Virology 00:45
Nobel Prizes and Life Sciences by Erling Norrby 1:18, 52:10
Nobel Prizes and Nature’s Surprises by Erling Norrby 1:18, 57:59
Nobel Prizes and Notable Discoveries by Erling Norrby 1:18, 1:06:10
Nobel Prizes: Cancer, Vision and the Genetic Code by Erling Norrby 2:39, 54:24
Polio and Nobel Prizes (Ann Neurol) 32:33
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV Special: Call me David Tuller

September 3, 2019

David Tuller returns to talk about his efforts of the past year to expose the methodological and ethical problems with the PACE and Lightning trials for therapy of ME/CFS.

Host: Vincent Racaniello

Guest: David Tuller

Click arrow to play
Download TWiV Special (44 MB .mp3, 73 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 563: BLT on mice

September 1, 2019

The TWiVologists consider whether to receive an influenza vaccine in August (in the northern hemisphere), and mice implanted with human lung fragments for studying microbial pathogens.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

Click arrow to play
Download TWiV 563 (55 MB .mp3, 91 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Waning of influenza vaccine protection (Clin Inf Dis) 20:42
Precision mouse models for microbial pathogenesis (Nat Biotech) 33:55
Letters read on TWiV 563 9:50, 58:07
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:17:18

Brianne – Why we need to increase diversity in the immunology research community
Alan – Stock photos of vaccination that don’t suck
Kathy – Sample size calculator
Vincent – How Economics Shapes Science by Paula Stephan

Listener Picks

Melinda – Zome Tools

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 562: Take a breath

August 25, 2019

TWiV travels to Rutgers University to speak with Brad, Kay, Siobain, and Kim about their careers and their work on viruses of plants, fungi, bacteria, diatoms, and coccolithophores.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guests: Brad Hillman, Kay Bidle, Siobain Duffy, and Kim Thamatrakoln

Click arrow to play
Download TWiV 562 (77 MB .mp3, 127 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Viruses of plant-interacting fungi (Adv Virus Res) 49:49
Why are RNA virus mutation rates so damn high? (PLoS Biol) 59:59
CRESS viruses (Adv Virus Res) 1:07:32
Coccolithovirus facilitation of carbon export in North Atlantic (Nat Micro) 1:18:04, 1:22:49
Silicon limitation facilitates virus infection of marine diatoms (Nat Micro) 1:40:22
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 561: Hot or not

August 18, 2019

The Autonomous CollecTWiVe reveal two effective treatments for Ebolavirus infection, how a virus in a fungus confers heat tolerance to a plant, and dampened inflammation as a mechanism for bat tolerance to viral infection.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

Click arrow to play
Download TWiV 561 (57 MB .mp3, 93 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Two new and effective Ebolavirus treatments (NIH, Nature) 3:16
A virus in a fungus in a plant (Science) 20:33
Dampened NLRP3-mediated inflammation in bats (Nat Micro) 32:55
Bat tolerance to virus infection (Nat Micro) 33:55
Image credit
Letters read on TWiV 561 1:07:27
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:18:03

Brianne – Deaf student makes sign language terms to communicate science
Alan – Show Your Stripes
Vincent – Sixty Years of Discovery

Listener Picks

Eric – This drug could end HIV – why hasn’t it?

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 560: CEIRS, influenza and company

August 11, 2019

From the meeting of the Centers of Excellence for Influenza Research and Surveillance, Vincent speaks with Alan, Florian and Jennifer about their careers, the purpose of CEIRS, universal influenza vaccines, and cellular responses to infection in pediatric populations.

Guests: Alan Embry, Florian Krammer, and Jennifer Nayak

Host: Vincent Racaniello

Click arrow to play
Download TWiV 560 (37 MB .mp3, 61 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

NIAID CEIRS 13:57
12th CEIRS meeting summary (pdf) 14:08
Antibody response to influenza virus (Nat Rev Micro) 46:01
Influenza virus CD4 T cells in children and young adults (Sci Rep) 53:58
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 559: Nectin connection what’s your infection?

August 4, 2019

The complete TWiV team give a report on the Ebola virus outbreak in DRC, and reveal that cell surface nectin proteins cause the transfer of cytoplasmic cargo, including measles virus, between cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit,Kathy Spindler, and Brianne Barker

Click arrow to play
Download TWiV 559 (65 MB .mp3, 108 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!