TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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Weekly Picks 1:33:41

BrianneCOVID-19: a disaster five years in the making
AlanThe Tyranny of Merit
RichRacism Makes Me Question Everything. I Got the Vaccine Anyway
Kathy – The Transcontinental Burrito Tunnel
VincentTrudy Rey’s YouTube Channel

Listener Picks

JeffRebecca Lee Smith on Left Right and Center
RyanPerfect Strangers (clip)

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and blood clots, and long COVID and the effect of vaccines.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:20:38

DicksonLet us now praise tiny ants
BrianneSmall-school science
RichSmallpox ‘virus squads’ and the mandatory vaccinations upheld by the Supreme Court
KathyThe Transcontinental Burrito Tunnel
VincentGlass music by Robert Tiso

Intro music is by Ronald Jenkees

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Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct randomized clinical trials, how this treatment has fared and his hopes for the future.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: Arturo Casadevall

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Weekly Picks 1:42:35

BrianneThe Ocean’s Youngest Monsters Are Ready for Glamour Shots
Alan7 Billion Humans
Rich15 Fascinating Animal X-Rays From the Oregon Zoo
VincentRespiratory pathogen trends

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #56, Daniel Griffin notes increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world conditions, and improvement of long COVID after vaccination.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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John, Monica, and Davida join TWiV to discuss development of a method to detect SARS-CoV-2 in raw sewage from all 14 of New York City’s treatment plants, and its use to determine the presence of the genome throughout the pandemic and detection of genome mutations from variants of concern.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: John Dennehy, Davida Smyth, and Monica Trujillo

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Weekly Picks 1:45:00

Dickson250,000 Dominoes
BrianneUsing RT-PCR in COVID-19 Testing
RichBeaded Lacewings Can Take Down Six Termites With A Single Fart
KathyTracking the COVID code
VincentAdministering vaccines to adults

Intro music is by Ronald Jenkees

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Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in convalescent patients and vaccinees, and whether a next generation vaccine should include more viral proteins than spike.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Alessandro Sette

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Weekly Picks 1:46:29

Alan – The Disinformation Dozen report
RichNo needle, but the damage was done
KathyZinn art  David Zinn
VincentClueless Wall Street Journal Op-Ed Endorses PACE as “Prevailing View” Among Docs

Listener Picks

JustinFinnish astrophotographer spends 12 years creating a Milky Way mosaic

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on asymptomatic infections, vaccine safety in PASC patients, and early use of aspirin associated with decreased mortality.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection.

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, Brianne Barker, and Amy Rosenfeld

Guest: Susan Weiss

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Weekly Picks 1:55:18

BrianneTiktok of How mRNA Vaccines Work
AlanDark
RichUnmixing Color Machine (Ultra Laminar Reversible Flow) – Smarter Every Day 217
AmyMOMA Calder exhibit, reviewed in NYTimes
VincentRipple Training (free YouTube channel)

Listener Picks

Ruth100 million year old seafloor bacteria resuscitated
IradisLinda Zall, CIA spy for science

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #54, Daniel Griffin covers effectiveness of 3 vs 6 ft physical distancing, effectiveness of masks, physical distancing, and eye shields, second vaccine dose completion, alleviation of COVID-19 symptoms after vaccination, vaccine trials in children, and IDSA approval of a mAb cocktail.

Hosts: Daniel Griffin and Vincent Racaniello

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Download TWiV 733 (27 MB .mp3, 45 min)
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Intro music is by Ronald Jenkees

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