anisakis lifecycleHosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

Vincent, Dickson, and Daniel solve their fishy tale, and present a new case study for your consumption.

Download TWiP #93 (65 MB .mp3, 89 minutes).

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Case study for TWiP 93

April 2015 a 177 lb 5ft 10in 39 yo man seen as outpatient in ID clinic, reports 2 y ago had issues with constipation on and off; throat hurts; feels closing when lies down. For several years has had skin irritation on upper chest and arms. Tried to donate blood, was rejected, told to see doctor.

Emigrated to US from El Salvador 2002, married, reports no extramarital sex, smokes 2-3 cigs/day, now quit; had drinking issue in past, no more; was agricultural worker in rural part of El Salvador; has history of asthma, on a number of medicines, including steriod nasal spray, inhaler, no visual problems, healthy appearing, not allergic to medicines. Family history: mother heart attack and diabetes; father peptic ulcer disease.

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ascaris adultsHosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

Vincent, Dickson, and Daniel discuss how fluctuation in the price of guinea pig food could help transmission of the agent of Chagas disease, and present a new case study for your consumption.

Download TWiP #92 (73 MB .mp3, 100 minutes).

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  • Ascaris on TWiP 21
  • Ascaris lumbricoides life cycle (jpg)
  • Child with distended abdomen due to Ascaris (jpg)
  • Bottlenecks and Chagas disease (Proc Biol Soc)
  • Letters read on TWiP 92

Case study for TWiP 92

A 20 yo Japanese female student went to the emergency room with severe abdominal pain. nausea, had vomited. Had just enjoyed homemade sushi an hour or two previuosly. She prepared the sushi: rice, salmon, tuna rolls. Salmon was local, caught by boyfriend. Tuna from store, sushi grade. No past medical history, mother with anemia. Takes oral contraceptives. No toxic habits. No travel. Monogamous. Temp 100.2, bp 140/90, hr high 90s, breathing upper teens. Physical exam normal except appears distressed in pain, belly extended, tender in left upper quadrant. Friends ate sushi but no one else got sick. All guests ate both types of fish.

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GIEHosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

Vincent, Dickson, and Daniel review how Viagra might be used to block transmission of Plasmodium falciparum, and introduce a new case study.

Download TWiP #91 (65 MB .mp3, 89 minutes).

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plasmodium bloodHosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

Vincent, Dickson, and Daniel discuss identification of an erythrocyte protein essential for invasion of Plasmodium falciparum, and introduce a new case study.

Download TWiP #90 (88 MB .mp3, 121 minutes).

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differential_counterHosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

Vincent, Dickson, and Daniel reveal last week’s case study and introduce a new one concerning a patient who traveled to Belize.

Download TWiP #89 (68 MB .mp3, 94 minutes).

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mitogenic pathwayHosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

Vincent, Dickson, and Daniel discuss how a secreted protein from the protozoan parasite Theileria transforms its host cells via a cellular proto-oncogene.

Download TWiP #88 (82 MB .mp3, 114 minutes).

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TrypanosomaBrucei ProcyclicTrypomastigote SEMHosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

Vincent, Dickson, and Daniel review new insight into antigenic variation in trypanosomes, reveal the difficult solution to the last case study, and  present another mystery for your solving.

Download TWiP #87 (55 MB .mp3, 77 minutes).

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loa microfilariaeHosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

Vincent, Dickson, and Daniel discuss how filarial infection modulates the immune response to mycobacterial infection, and reveal a new case study.

Download TWiP #86 (90 MB .mp3, 125 minutes).

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crawfishHosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

Vincent, Dickson, and Daniel explain how trypanolytic factor forms membrane channels to lyse trypanosomes, and present a new case study.

Download TWiP #85 (79 MB .mp3, 110 minutes).

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500px-Heavy_chain_and_common_antibody.svgHosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

Vincent, Dickson, and Daniel consider the delivery of anti-trypanosome nanobodies to the tsetse fly via a bacterial symbiont, and present a new case study.

Download TWiP #84 (78 MB .mp3, 106 minutes).

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