Matters Microbial #89: Can AI Point Us to New Antibiotics

May 1, 2025

Today, Dr. Amir Mitchell, Associate Professor of Systems Biology at the University of Massachusetts Medical School, joins the #QualityQuorum to discuss using artificial intelligence to develop new and effective antibiotics in our endless battle against drug-resistant microbes.

Host: Mark O. Martin

Guest: Amir MItchell

Download MM#89 (40 MB mp3, 67 min)
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  • An article exploring the impact of the microbiome on drug effectiveness.
  • A blog post discussing the relationship between the gut microbiome and creosote metabolism in wood rats.
  • An essay about the threat of antibiotic resistance.
  • A more scholarly article on this topic.
  • A CDC report of the rise of antibiotic resistance.
  • A very moving TED talk on this topic.
  • An overview of antibiotic resistance mechanisms.
  • A video from Dr. Michael Baym’s laboratory demonstrating how rapidly antibiotic resistance can occur.
  • An essay discussing the use of artificial intelligence in the search for new antibiotics. 
  • An article from Dr. Mitchell’s research group discussing his approach to identity new antimicrobial compounds.
  • Dr. Mitchell’s faculty website.
  • Dr. Mitchell’s very interesting research team website.

Intro music is by Reber Clark

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